The effects of synbiotic supplementation on oxidative stress and clinical symptoms in women with migraine: A double‐blind, placebo‐controlled, randomized trial
Oxidative stress may play an important role in migraine pathogenesis. This randomized controlled trial aimed to investigate the effect of 12 weeks synbiotic supplementation on the oxidative stress and clinical symptoms of migraine in eighty women. The effect of the intervention on the total antioxid...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-11-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646462100387X |
| _version_ | 1819110138495107072 |
|---|---|
| author | Abed Ghavami Fariborz Khorvash Saman Khalesi Zahra Heidari Gholamreza Askari |
| author_facet | Abed Ghavami Fariborz Khorvash Saman Khalesi Zahra Heidari Gholamreza Askari |
| author_sort | Abed Ghavami |
| collection | DOAJ |
| description | Oxidative stress may play an important role in migraine pathogenesis. This randomized controlled trial aimed to investigate the effect of 12 weeks synbiotic supplementation on the oxidative stress and clinical symptoms of migraine in eighty women. The effect of the intervention on the total antioxidant capacity (TAC), nitric oxide (NO), oxidative stress index (OSI), total oxidant status (TOS), migraine index (MI), headache diary result (HDR) and migraine headache index score (MHIS) were investigated using bivariate comparison. Synbiotic supplementation improved TAC (381.77 vs 43.17 nmol/ml, P = 0.034), and reduced NO (-4.62 vs 0.55 nmol/ml, P = 0.021), OSI levels (-0.33 vs 0.0009, P = 0.027), and MI (-8.27 vs −3.20, P = 0.013) compared to placebo. A positive correlation between the severity of migraine headache and NO level was observed following synbiotic supplementation (r = 0.44, P = 0.002). Synbiotics may reduce oxidative stress and improve migraine symptoms in women and help as a supplemental therapy in managing migraine headaches. |
| first_indexed | 2024-12-22T03:36:57Z |
| format | Article |
| id | doaj.art-f9dcfbcf6ce846e49842f3a88e9202a3 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-22T03:36:57Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-f9dcfbcf6ce846e49842f3a88e9202a32022-12-21T18:40:21ZengElsevierJournal of Functional Foods1756-46462021-11-0186104738The effects of synbiotic supplementation on oxidative stress and clinical symptoms in women with migraine: A double‐blind, placebo‐controlled, randomized trialAbed Ghavami0Fariborz Khorvash1Saman Khalesi2Zahra Heidari3Gholamreza Askari4Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, IranNeurology Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranPhysical Activity Research Group, Appleton Institute and School of Health Medical and Applied Sciences, Central Queensland University, Brisbane, AustraliaDepartment of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran; Corresponding author.Oxidative stress may play an important role in migraine pathogenesis. This randomized controlled trial aimed to investigate the effect of 12 weeks synbiotic supplementation on the oxidative stress and clinical symptoms of migraine in eighty women. The effect of the intervention on the total antioxidant capacity (TAC), nitric oxide (NO), oxidative stress index (OSI), total oxidant status (TOS), migraine index (MI), headache diary result (HDR) and migraine headache index score (MHIS) were investigated using bivariate comparison. Synbiotic supplementation improved TAC (381.77 vs 43.17 nmol/ml, P = 0.034), and reduced NO (-4.62 vs 0.55 nmol/ml, P = 0.021), OSI levels (-0.33 vs 0.0009, P = 0.027), and MI (-8.27 vs −3.20, P = 0.013) compared to placebo. A positive correlation between the severity of migraine headache and NO level was observed following synbiotic supplementation (r = 0.44, P = 0.002). Synbiotics may reduce oxidative stress and improve migraine symptoms in women and help as a supplemental therapy in managing migraine headaches.http://www.sciencedirect.com/science/article/pii/S175646462100387XClinical symptomsMigraineOxidative stressSynbiotics |
| spellingShingle | Abed Ghavami Fariborz Khorvash Saman Khalesi Zahra Heidari Gholamreza Askari The effects of synbiotic supplementation on oxidative stress and clinical symptoms in women with migraine: A double‐blind, placebo‐controlled, randomized trial Journal of Functional Foods Clinical symptoms Migraine Oxidative stress Synbiotics |
| title | The effects of synbiotic supplementation on oxidative stress and clinical symptoms in women with migraine: A double‐blind, placebo‐controlled, randomized trial |
| title_full | The effects of synbiotic supplementation on oxidative stress and clinical symptoms in women with migraine: A double‐blind, placebo‐controlled, randomized trial |
| title_fullStr | The effects of synbiotic supplementation on oxidative stress and clinical symptoms in women with migraine: A double‐blind, placebo‐controlled, randomized trial |
| title_full_unstemmed | The effects of synbiotic supplementation on oxidative stress and clinical symptoms in women with migraine: A double‐blind, placebo‐controlled, randomized trial |
| title_short | The effects of synbiotic supplementation on oxidative stress and clinical symptoms in women with migraine: A double‐blind, placebo‐controlled, randomized trial |
| title_sort | effects of synbiotic supplementation on oxidative stress and clinical symptoms in women with migraine a double blind placebo controlled randomized trial |
| topic | Clinical symptoms Migraine Oxidative stress Synbiotics |
| url | http://www.sciencedirect.com/science/article/pii/S175646462100387X |
| work_keys_str_mv | AT abedghavami theeffectsofsynbioticsupplementationonoxidativestressandclinicalsymptomsinwomenwithmigraineadoubleblindplacebocontrolledrandomizedtrial AT fariborzkhorvash theeffectsofsynbioticsupplementationonoxidativestressandclinicalsymptomsinwomenwithmigraineadoubleblindplacebocontrolledrandomizedtrial AT samankhalesi theeffectsofsynbioticsupplementationonoxidativestressandclinicalsymptomsinwomenwithmigraineadoubleblindplacebocontrolledrandomizedtrial AT zahraheidari theeffectsofsynbioticsupplementationonoxidativestressandclinicalsymptomsinwomenwithmigraineadoubleblindplacebocontrolledrandomizedtrial AT gholamrezaaskari theeffectsofsynbioticsupplementationonoxidativestressandclinicalsymptomsinwomenwithmigraineadoubleblindplacebocontrolledrandomizedtrial AT abedghavami effectsofsynbioticsupplementationonoxidativestressandclinicalsymptomsinwomenwithmigraineadoubleblindplacebocontrolledrandomizedtrial AT fariborzkhorvash effectsofsynbioticsupplementationonoxidativestressandclinicalsymptomsinwomenwithmigraineadoubleblindplacebocontrolledrandomizedtrial AT samankhalesi effectsofsynbioticsupplementationonoxidativestressandclinicalsymptomsinwomenwithmigraineadoubleblindplacebocontrolledrandomizedtrial AT zahraheidari effectsofsynbioticsupplementationonoxidativestressandclinicalsymptomsinwomenwithmigraineadoubleblindplacebocontrolledrandomizedtrial AT gholamrezaaskari effectsofsynbioticsupplementationonoxidativestressandclinicalsymptomsinwomenwithmigraineadoubleblindplacebocontrolledrandomizedtrial |