NAD+-dependent mechanism of pathological axon degeneration
Pathological axon degeneration is broadly observed in neurodegenerative diseases. This unique process of axonal pathology could directly interfere with the normal functions of neurocircuitries and contribute to the onset of clinical symptoms in patients. It has been increasingly recognized that func...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | Cell Insight |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772892722000165 |
| _version_ | 1818473011283492864 |
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| author | Ying Cao Yi Wang Jing Yang |
| author_facet | Ying Cao Yi Wang Jing Yang |
| author_sort | Ying Cao |
| collection | DOAJ |
| description | Pathological axon degeneration is broadly observed in neurodegenerative diseases. This unique process of axonal pathology could directly interfere with the normal functions of neurocircuitries and contribute to the onset of clinical symptoms in patients. It has been increasingly recognized that functional preservation of axonal structures is an indispensable part of therapeutic strategies for treating neurological disorders. In the past decades, the research field has witnessed significant breakthroughs in understanding the stereotyped self-destruction of axons upon neurodegenerative insults, which is distinct from all the known types of programmed cell death. In particular, the novel NAD+-dependent mechanism involving the WLDs, NMNAT2, and SARM1 proteins has emerged. This review summarizes the landmark discoveries elucidating the molecular pathway of pathological axon degeneration and highlights the evolving concept that neurodegeneration would be intrinsically linked to NAD+ and energy metabolism. |
| first_indexed | 2024-04-14T04:15:52Z |
| format | Article |
| id | doaj.art-f9ddad4ebfeb4ed198a042436eaa1843 |
| institution | Directory Open Access Journal |
| issn | 2772-8927 |
| language | English |
| last_indexed | 2024-04-14T04:15:52Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Insight |
| spelling | doaj.art-f9ddad4ebfeb4ed198a042436eaa18432022-12-22T02:12:51ZengElsevierCell Insight2772-89272022-04-0112100019NAD+-dependent mechanism of pathological axon degenerationYing Cao0Yi Wang1Jing Yang2Center for Life Sciences, Peking University, Beijing, 100871, China; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, ChinaCenter for Life Sciences, Peking University, Beijing, 100871, China; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, ChinaCenter for Life Sciences, Peking University, Beijing, 100871, China; State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, 100871, China; IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100871, China; Chinese Institute for Brain Research, Beijing, 102206, China; Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, 518055, China; Corresponding author. Center for Life Sciences, Peking University, Beijing, 100871, China.Pathological axon degeneration is broadly observed in neurodegenerative diseases. This unique process of axonal pathology could directly interfere with the normal functions of neurocircuitries and contribute to the onset of clinical symptoms in patients. It has been increasingly recognized that functional preservation of axonal structures is an indispensable part of therapeutic strategies for treating neurological disorders. In the past decades, the research field has witnessed significant breakthroughs in understanding the stereotyped self-destruction of axons upon neurodegenerative insults, which is distinct from all the known types of programmed cell death. In particular, the novel NAD+-dependent mechanism involving the WLDs, NMNAT2, and SARM1 proteins has emerged. This review summarizes the landmark discoveries elucidating the molecular pathway of pathological axon degeneration and highlights the evolving concept that neurodegeneration would be intrinsically linked to NAD+ and energy metabolism.http://www.sciencedirect.com/science/article/pii/S2772892722000165NAD+ metabolismEnergy deficitPathological axon degenerationWlds mutationSARM1 |
| spellingShingle | Ying Cao Yi Wang Jing Yang NAD+-dependent mechanism of pathological axon degeneration Cell Insight NAD+ metabolism Energy deficit Pathological axon degeneration Wlds mutation SARM1 |
| title | NAD+-dependent mechanism of pathological axon degeneration |
| title_full | NAD+-dependent mechanism of pathological axon degeneration |
| title_fullStr | NAD+-dependent mechanism of pathological axon degeneration |
| title_full_unstemmed | NAD+-dependent mechanism of pathological axon degeneration |
| title_short | NAD+-dependent mechanism of pathological axon degeneration |
| title_sort | nad dependent mechanism of pathological axon degeneration |
| topic | NAD+ metabolism Energy deficit Pathological axon degeneration Wlds mutation SARM1 |
| url | http://www.sciencedirect.com/science/article/pii/S2772892722000165 |
| work_keys_str_mv | AT yingcao naddependentmechanismofpathologicalaxondegeneration AT yiwang naddependentmechanismofpathologicalaxondegeneration AT jingyang naddependentmechanismofpathologicalaxondegeneration |