Postnatal Changes of Somatostatin Expression in Hippocampi of C57BL/6 Mice; Modulation of Neuroblast Differentiation in the Hippocampus
(1) Background: Somatostatin (SST) exhibits expressional changes in the brain during development, but its role is not still clear in brain development. (2) Methods: We investigated postnatal SST expression and its effects on hippocampal neurogenesis via administering SST subcutaneously to P7 mice fo...
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MDPI AG
2023-01-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/10/2/81 |
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| author | Dae Young Yoo Woosuk Kim Hyo Young Jung In Koo Hwang |
| author_facet | Dae Young Yoo Woosuk Kim Hyo Young Jung In Koo Hwang |
| author_sort | Dae Young Yoo |
| collection | DOAJ |
| description | (1) Background: Somatostatin (SST) exhibits expressional changes in the brain during development, but its role is not still clear in brain development. (2) Methods: We investigated postnatal SST expression and its effects on hippocampal neurogenesis via administering SST subcutaneously to P7 mice for 7 days. (3) Results: In the hippocampal CA1 region, SST immunoreactivity reaches peak at P14. However, SST immunoreactivity significantly decreased at P21. In the CA2/3 region, the SST expression pattern was similar to the CA1, and SST-immunoreactive cells were most abundant at P14. In the dentate gyrus, SST-immunoreactive cells were most abundant at P7 and P14 in the polymorphic layer; as in CA1-3 regions, the immunoreactivity decreased at P21. To elucidate the role of SST in postnatal development, we administered SST subcutaneously to P7 mice for 7 days. In the subgranular zone of the hippocampal dentate gyrus, a significant increase was observed in immunoreactivity of doublecortin (DCX)-positive neuroblast after administration of SST.; (4) Conclusions: SST expression in the hippocampal sub-regions is transiently increased during the postnatal formation of the hippocampus and decreases after P21. In addition, SST is involved in neuroblast differentiation in the dentate gyrus of the hippocampus. |
| first_indexed | 2024-03-11T08:02:26Z |
| format | Article |
| id | doaj.art-f9ddf2a216714009b41288fc119784e5 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-11T08:02:26Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-f9ddf2a216714009b41288fc119784e52023-11-16T23:45:22ZengMDPI AGVeterinary Sciences2306-73812023-01-011028110.3390/vetsci10020081Postnatal Changes of Somatostatin Expression in Hippocampi of C57BL/6 Mice; Modulation of Neuroblast Differentiation in the HippocampusDae Young Yoo0Woosuk Kim1Hyo Young Jung2In Koo Hwang3Department of Anatomy and Convergence Medical Science, Institute of Health Science, Tyrosine Peptide Multiuse Research Group, College of Medicine, Gyeongsang National University, Jinju 52727, Republic of KoreaDepartment of Anatomy, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of KoreaDepartment of Veterinary Medicine & Institute of Veterinary Science, Chungnam National University, Daejeon 34134, Republic of KoreaDepartment of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea(1) Background: Somatostatin (SST) exhibits expressional changes in the brain during development, but its role is not still clear in brain development. (2) Methods: We investigated postnatal SST expression and its effects on hippocampal neurogenesis via administering SST subcutaneously to P7 mice for 7 days. (3) Results: In the hippocampal CA1 region, SST immunoreactivity reaches peak at P14. However, SST immunoreactivity significantly decreased at P21. In the CA2/3 region, the SST expression pattern was similar to the CA1, and SST-immunoreactive cells were most abundant at P14. In the dentate gyrus, SST-immunoreactive cells were most abundant at P7 and P14 in the polymorphic layer; as in CA1-3 regions, the immunoreactivity decreased at P21. To elucidate the role of SST in postnatal development, we administered SST subcutaneously to P7 mice for 7 days. In the subgranular zone of the hippocampal dentate gyrus, a significant increase was observed in immunoreactivity of doublecortin (DCX)-positive neuroblast after administration of SST.; (4) Conclusions: SST expression in the hippocampal sub-regions is transiently increased during the postnatal formation of the hippocampus and decreases after P21. In addition, SST is involved in neuroblast differentiation in the dentate gyrus of the hippocampus.https://www.mdpi.com/2306-7381/10/2/81somatostatinpostnatalhippocampusneuroblast differentiation |
| spellingShingle | Dae Young Yoo Woosuk Kim Hyo Young Jung In Koo Hwang Postnatal Changes of Somatostatin Expression in Hippocampi of C57BL/6 Mice; Modulation of Neuroblast Differentiation in the Hippocampus Veterinary Sciences somatostatin postnatal hippocampus neuroblast differentiation |
| title | Postnatal Changes of Somatostatin Expression in Hippocampi of C57BL/6 Mice; Modulation of Neuroblast Differentiation in the Hippocampus |
| title_full | Postnatal Changes of Somatostatin Expression in Hippocampi of C57BL/6 Mice; Modulation of Neuroblast Differentiation in the Hippocampus |
| title_fullStr | Postnatal Changes of Somatostatin Expression in Hippocampi of C57BL/6 Mice; Modulation of Neuroblast Differentiation in the Hippocampus |
| title_full_unstemmed | Postnatal Changes of Somatostatin Expression in Hippocampi of C57BL/6 Mice; Modulation of Neuroblast Differentiation in the Hippocampus |
| title_short | Postnatal Changes of Somatostatin Expression in Hippocampi of C57BL/6 Mice; Modulation of Neuroblast Differentiation in the Hippocampus |
| title_sort | postnatal changes of somatostatin expression in hippocampi of c57bl 6 mice modulation of neuroblast differentiation in the hippocampus |
| topic | somatostatin postnatal hippocampus neuroblast differentiation |
| url | https://www.mdpi.com/2306-7381/10/2/81 |
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