Informatics on Drug Repurposing for Breast Cancer
Hui Zhou,1,2,* Hongdou Liu,3,* Yan Yu,3 Xiao Yuan,3,4 Ling Xiao5 1Department of Lymphoma and Hematology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China; 2Department of Lymphoma and Hematology, Hunan...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-06-01
|
| Series: | Drug Design, Development and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/informatics-on-drug-repurposing-for-breast-cancer-peer-reviewed-fulltext-article-DDDT |
| _version_ | 1797789397103411200 |
|---|---|
| author | Zhou H Liu H Yu Y Yuan X Xiao L |
| author_facet | Zhou H Liu H Yu Y Yuan X Xiao L |
| author_sort | Zhou H |
| collection | DOAJ |
| description | Hui Zhou,1,2,* Hongdou Liu,3,* Yan Yu,3 Xiao Yuan,3,4 Ling Xiao5 1Department of Lymphoma and Hematology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China; 2Department of Lymphoma and Hematology, Hunan Cancer Hospital, Changsha, Hunan, People’s Republic of China; 3Department of Laboratory Diagnosis, Changsha Kingmed Center for Clinical Laboratory, Changsha, Hunan, People’s Republic of China; 4Department of Laboratory Diagnosis, Guangzhou Kingmed Center for Clinical Laboratory, Guangzhou, Guangdong, People’s Republic of China; 5Department of Histology and Embryology of Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ling Xiao, Department of Histology and Embryology of Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China, Tel +86-13974871376, Email xiaolingcsu@csu.edu.cn Xiao Yuan, Changsha Kingmed Center for Clinical Laboratory, Changsha, Hunan, People’s Republic of China, Tel +86-18662520739, Email hn-yuanxiao@kingmed.com.cnAbstract: Moving a new drug from bench to bedside is a long and arduous process. The tactic of drug repurposing, which solves “new” diseases with “old” existing drugs, is more efficient and economical than conventional ab-initio way for drug development. Information technology has dramatically changed the paradigm of biomedical research in the new century, and drug repurposing studies have been significantly accelerated by implementing informatics techniques related to genomics, systems biology and biophysics during the past few years. A series of remarkable achievements in this field comes with the practical applications of in silico approaches including transcriptomic signature matching, gene-connection-based scanning, and simulated structure docking in repositioning drug therapies against breast cancer. In this review, we systematically curated these impressive accomplishments with summarization of the main findings on potentially repurposable drugs, and provide our insights into the current issues as well as future directions of the field. With the prospective improvement in reliability, the computer-assisted repurposing strategy will play a more critical role in drug research and development.Keywords: drug repurposing, breast cancer, CMap, network, molecular docking |
| first_indexed | 2024-03-13T01:50:03Z |
| format | Article |
| id | doaj.art-f9de7bb95ddd48b790597983a23f88e9 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-03-13T01:50:03Z |
| publishDate | 2023-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-f9de7bb95ddd48b790597983a23f88e92023-07-02T19:49:17ZengDove Medical PressDrug Design, Development and Therapy1177-88812023-06-01Volume 171933194384758Informatics on Drug Repurposing for Breast CancerZhou HLiu HYu YYuan XXiao LHui Zhou,1,2,* Hongdou Liu,3,* Yan Yu,3 Xiao Yuan,3,4 Ling Xiao5 1Department of Lymphoma and Hematology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China; 2Department of Lymphoma and Hematology, Hunan Cancer Hospital, Changsha, Hunan, People’s Republic of China; 3Department of Laboratory Diagnosis, Changsha Kingmed Center for Clinical Laboratory, Changsha, Hunan, People’s Republic of China; 4Department of Laboratory Diagnosis, Guangzhou Kingmed Center for Clinical Laboratory, Guangzhou, Guangdong, People’s Republic of China; 5Department of Histology and Embryology of Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ling Xiao, Department of Histology and Embryology of Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China, Tel +86-13974871376, Email xiaolingcsu@csu.edu.cn Xiao Yuan, Changsha Kingmed Center for Clinical Laboratory, Changsha, Hunan, People’s Republic of China, Tel +86-18662520739, Email hn-yuanxiao@kingmed.com.cnAbstract: Moving a new drug from bench to bedside is a long and arduous process. The tactic of drug repurposing, which solves “new” diseases with “old” existing drugs, is more efficient and economical than conventional ab-initio way for drug development. Information technology has dramatically changed the paradigm of biomedical research in the new century, and drug repurposing studies have been significantly accelerated by implementing informatics techniques related to genomics, systems biology and biophysics during the past few years. A series of remarkable achievements in this field comes with the practical applications of in silico approaches including transcriptomic signature matching, gene-connection-based scanning, and simulated structure docking in repositioning drug therapies against breast cancer. In this review, we systematically curated these impressive accomplishments with summarization of the main findings on potentially repurposable drugs, and provide our insights into the current issues as well as future directions of the field. With the prospective improvement in reliability, the computer-assisted repurposing strategy will play a more critical role in drug research and development.Keywords: drug repurposing, breast cancer, CMap, network, molecular dockinghttps://www.dovepress.com/informatics-on-drug-repurposing-for-breast-cancer-peer-reviewed-fulltext-article-DDDTdrug repurposingbreast cancercmapnetworkmolecular docking |
| spellingShingle | Zhou H Liu H Yu Y Yuan X Xiao L Informatics on Drug Repurposing for Breast Cancer Drug Design, Development and Therapy drug repurposing breast cancer cmap network molecular docking |
| title | Informatics on Drug Repurposing for Breast Cancer |
| title_full | Informatics on Drug Repurposing for Breast Cancer |
| title_fullStr | Informatics on Drug Repurposing for Breast Cancer |
| title_full_unstemmed | Informatics on Drug Repurposing for Breast Cancer |
| title_short | Informatics on Drug Repurposing for Breast Cancer |
| title_sort | informatics on drug repurposing for breast cancer |
| topic | drug repurposing breast cancer cmap network molecular docking |
| url | https://www.dovepress.com/informatics-on-drug-repurposing-for-breast-cancer-peer-reviewed-fulltext-article-DDDT |
| work_keys_str_mv | AT zhouh informaticsondrugrepurposingforbreastcancer AT liuh informaticsondrugrepurposingforbreastcancer AT yuy informaticsondrugrepurposingforbreastcancer AT yuanx informaticsondrugrepurposingforbreastcancer AT xiaol informaticsondrugrepurposingforbreastcancer |