Assessment of the Genetic Characteristics of a Generation Born during a Long-Term Socioeconomic Crisis
Background: A socioeconomic crisis in Russia lasted from 1991 to 1998 and was accompanied by a sharp drop in the birth rate. The main factor that influenced the refusal to have children during this period is thought to be prolonged social stress. Methods: comparing frequencies of common gene variant...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/14/11/2064 |
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| author | Svetlana V. Mikhailova Dinara E. Ivanoshchuk Pavel S. Orlov Ahmad Bairqdar Maksim S. Anisimenko Diana V. Denisova |
| author_facet | Svetlana V. Mikhailova Dinara E. Ivanoshchuk Pavel S. Orlov Ahmad Bairqdar Maksim S. Anisimenko Diana V. Denisova |
| author_sort | Svetlana V. Mikhailova |
| collection | DOAJ |
| description | Background: A socioeconomic crisis in Russia lasted from 1991 to 1998 and was accompanied by a sharp drop in the birth rate. The main factor that influenced the refusal to have children during this period is thought to be prolonged social stress. Methods: comparing frequencies of common gene variants associated with stress-induced diseases among generations born before, after, and during this crisis may show which genes may be preferred under the pressure of natural selection during periods of increased social stress in urban populations. Results: In the “crisis” group, a statistically significant difference from the other two groups was found in rs6557168 frequency (<i>p</i> = 0.001); rs4522666 was not in the Hardy–Weinberg equilibrium in this group, although its frequency did not show a significant difference from the other groups (<i>p</i> = 0.118). Frequencies of VNTRs in <i>SLC6A3</i> and <i>MAOA</i> as well as common variants rs17689918 in <i>CRHR1</i>, rs1360780 in <i>FKBP5</i>, rs53576 in <i>OXTR</i>, rs12720071 and rs806377 in <i>CNR1</i>, rs4311 in <i>ACE</i>, rs1800497 in <i>ANKK1</i>, and rs7412 and rs429358 in <i>APOE</i> did not differ among the groups. Conclusions: a generation born during a period of prolonged destructive events may differ from the rest of the gene pool of the population in some variants associated with personality traits or stress-related disorders. |
| first_indexed | 2024-03-09T16:48:27Z |
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| id | doaj.art-f9dedd3195c3402e8b7a150859b4b954 |
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| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T16:48:27Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-f9dedd3195c3402e8b7a150859b4b9542023-11-24T14:44:02ZengMDPI AGGenes2073-44252023-11-011411206410.3390/genes14112064Assessment of the Genetic Characteristics of a Generation Born during a Long-Term Socioeconomic CrisisSvetlana V. Mikhailova0Dinara E. Ivanoshchuk1Pavel S. Orlov2Ahmad Bairqdar3Maksim S. Anisimenko4Diana V. Denisova5Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (ICG SB RAS), 10 Prospekt Ak. Lavrentyeva, 630090 Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (ICG SB RAS), 10 Prospekt Ak. Lavrentyeva, 630090 Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (ICG SB RAS), 10 Prospekt Ak. Lavrentyeva, 630090 Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (ICG SB RAS), 10 Prospekt Ak. Lavrentyeva, 630090 Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (ICG SB RAS), 10 Prospekt Ak. Lavrentyeva, 630090 Novosibirsk, RussiaInstitute of Internal and Preventive Medicine—Branch of ICG SB RAS, 175/1 Borisa Bogatkova Str., 630089 Novosibirsk, RussiaBackground: A socioeconomic crisis in Russia lasted from 1991 to 1998 and was accompanied by a sharp drop in the birth rate. The main factor that influenced the refusal to have children during this period is thought to be prolonged social stress. Methods: comparing frequencies of common gene variants associated with stress-induced diseases among generations born before, after, and during this crisis may show which genes may be preferred under the pressure of natural selection during periods of increased social stress in urban populations. Results: In the “crisis” group, a statistically significant difference from the other two groups was found in rs6557168 frequency (<i>p</i> = 0.001); rs4522666 was not in the Hardy–Weinberg equilibrium in this group, although its frequency did not show a significant difference from the other groups (<i>p</i> = 0.118). Frequencies of VNTRs in <i>SLC6A3</i> and <i>MAOA</i> as well as common variants rs17689918 in <i>CRHR1</i>, rs1360780 in <i>FKBP5</i>, rs53576 in <i>OXTR</i>, rs12720071 and rs806377 in <i>CNR1</i>, rs4311 in <i>ACE</i>, rs1800497 in <i>ANKK1</i>, and rs7412 and rs429358 in <i>APOE</i> did not differ among the groups. Conclusions: a generation born during a period of prolonged destructive events may differ from the rest of the gene pool of the population in some variants associated with personality traits or stress-related disorders.https://www.mdpi.com/2073-4425/14/11/2064stressgenetic predispositionpolymorphism<i>SLC6A3</i><i>MAOA</i><i>CRHR1</i> |
| spellingShingle | Svetlana V. Mikhailova Dinara E. Ivanoshchuk Pavel S. Orlov Ahmad Bairqdar Maksim S. Anisimenko Diana V. Denisova Assessment of the Genetic Characteristics of a Generation Born during a Long-Term Socioeconomic Crisis Genes stress genetic predisposition polymorphism <i>SLC6A3</i> <i>MAOA</i> <i>CRHR1</i> |
| title | Assessment of the Genetic Characteristics of a Generation Born during a Long-Term Socioeconomic Crisis |
| title_full | Assessment of the Genetic Characteristics of a Generation Born during a Long-Term Socioeconomic Crisis |
| title_fullStr | Assessment of the Genetic Characteristics of a Generation Born during a Long-Term Socioeconomic Crisis |
| title_full_unstemmed | Assessment of the Genetic Characteristics of a Generation Born during a Long-Term Socioeconomic Crisis |
| title_short | Assessment of the Genetic Characteristics of a Generation Born during a Long-Term Socioeconomic Crisis |
| title_sort | assessment of the genetic characteristics of a generation born during a long term socioeconomic crisis |
| topic | stress genetic predisposition polymorphism <i>SLC6A3</i> <i>MAOA</i> <i>CRHR1</i> |
| url | https://www.mdpi.com/2073-4425/14/11/2064 |
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