Three Different Genetic Risk Scores Based on Fatty Liver Index, Magnetic Resonance Imaging and Lipidomic for a Nutrigenetic Personalized Management of NAFLD: The Fatty Liver in Obesity Study
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the global population. The pathogenesis of NAFLD is complex; available data reveal that genetics and ascribed interactions with environmental factors may play an important role in the development of this morbid condition. The purpose of this i...
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| Format: | Article |
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MDPI AG
2021-06-01
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| author | Nuria Perez-Diaz-del-Campo Jose I. Riezu-Boj Bertha Araceli Marin-Alejandre J. Ignacio Monreal Mariana Elorz José Ignacio Herrero Alberto Benito-Boillos Fermín I. Milagro Josep A. Tur Itziar Abete M. Angeles Zulet J. Alfredo Martinez |
| author_facet | Nuria Perez-Diaz-del-Campo Jose I. Riezu-Boj Bertha Araceli Marin-Alejandre J. Ignacio Monreal Mariana Elorz José Ignacio Herrero Alberto Benito-Boillos Fermín I. Milagro Josep A. Tur Itziar Abete M. Angeles Zulet J. Alfredo Martinez |
| author_sort | Nuria Perez-Diaz-del-Campo |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) affects 25% of the global population. The pathogenesis of NAFLD is complex; available data reveal that genetics and ascribed interactions with environmental factors may play an important role in the development of this morbid condition. The purpose of this investigation was to assess genetic and non-genetic determinants putatively involved in the onset and progression of NAFLD after a 6-month weight loss nutritional treatment. A group of 86 overweight/obese subjects with NAFLD from the Fatty Liver in Obesity (FLiO) study were enrolled and metabolically evaluated at baseline and after 6 months. A pre-designed panel of 95 genetic variants related to obesity and weight loss was applied and analyzed. Three genetic risk scores (GRS) concerning the improvement on hepatic health evaluated by minimally invasive methods such as the fatty liver index (FLI) (GRS<sub>FLI</sub>), lipidomic-OWLiver<sup>®</sup>-test (GRS<sub>OWL</sub>) and magnetic resonance imaging (MRI) (GRS<sub>MRI</sub>), were derived by adding the risk alleles genotypes. Body composition, liver injury-related markers and dietary intake were also monitored. Overall, 23 SNPs were independently associated with the change in FLI, 16 SNPs with OWLiver<sup>®</sup>-test and 8 SNPs with MRI, which were specific for every diagnosis tool. After adjusting for gender, age and other related predictors (insulin resistance, inflammatory biomarkers and dietary intake at baseline) the calculated GRS<sub>FLI</sub>, GRS<sub>OWL</sub> and GRS<sub>MRI</sub> were major contributors of the improvement in hepatic status<sub>.</sub> Thus, fitted linear regression models showed a variance of 53% (adj. R<sup>2</sup> = 0.53) in hepatic functionality (FLI), 16% (adj. R<sup>2</sup> = 0.16) in lipidomic metabolism (OWLiver<sup>®</sup>-test) and 34% (adj. R<sup>2</sup> = 0.34) in liver fat content (MRI). These results demonstrate that three different genetic scores can be useful for the personalized management of NAFLD, whose treatment must rely on specific dietary recommendations guided by the measurement of specific genetic biomarkers. |
| first_indexed | 2024-03-10T10:26:54Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T10:26:54Z |
| publishDate | 2021-06-01 |
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| spelling | doaj.art-f9df1468fffb4af780ca92a756c10f2f2023-11-21T23:57:46ZengMDPI AGDiagnostics2075-44182021-06-01116108310.3390/diagnostics11061083Three Different Genetic Risk Scores Based on Fatty Liver Index, Magnetic Resonance Imaging and Lipidomic for a Nutrigenetic Personalized Management of NAFLD: The Fatty Liver in Obesity StudyNuria Perez-Diaz-del-Campo0Jose I. Riezu-Boj1Bertha Araceli Marin-Alejandre2J. Ignacio Monreal3Mariana Elorz4José Ignacio Herrero5Alberto Benito-Boillos6Fermín I. Milagro7Josep A. Tur8Itziar Abete9M. Angeles Zulet10J. Alfredo Martinez11Department of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, SpainCentre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, SpainDepartment of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, SpainNavarra Institute for Health Research (IdiSNA), 31008 Pamplona, SpainNavarra Institute for Health Research (IdiSNA), 31008 Pamplona, SpainNavarra Institute for Health Research (IdiSNA), 31008 Pamplona, SpainNavarra Institute for Health Research (IdiSNA), 31008 Pamplona, SpainDepartment of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, SpainBiomedical Research Centre Network in Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, SpainDepartment of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, SpainDepartment of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, SpainDepartment of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, SpainNon-alcoholic fatty liver disease (NAFLD) affects 25% of the global population. The pathogenesis of NAFLD is complex; available data reveal that genetics and ascribed interactions with environmental factors may play an important role in the development of this morbid condition. The purpose of this investigation was to assess genetic and non-genetic determinants putatively involved in the onset and progression of NAFLD after a 6-month weight loss nutritional treatment. A group of 86 overweight/obese subjects with NAFLD from the Fatty Liver in Obesity (FLiO) study were enrolled and metabolically evaluated at baseline and after 6 months. A pre-designed panel of 95 genetic variants related to obesity and weight loss was applied and analyzed. Three genetic risk scores (GRS) concerning the improvement on hepatic health evaluated by minimally invasive methods such as the fatty liver index (FLI) (GRS<sub>FLI</sub>), lipidomic-OWLiver<sup>®</sup>-test (GRS<sub>OWL</sub>) and magnetic resonance imaging (MRI) (GRS<sub>MRI</sub>), were derived by adding the risk alleles genotypes. Body composition, liver injury-related markers and dietary intake were also monitored. Overall, 23 SNPs were independently associated with the change in FLI, 16 SNPs with OWLiver<sup>®</sup>-test and 8 SNPs with MRI, which were specific for every diagnosis tool. After adjusting for gender, age and other related predictors (insulin resistance, inflammatory biomarkers and dietary intake at baseline) the calculated GRS<sub>FLI</sub>, GRS<sub>OWL</sub> and GRS<sub>MRI</sub> were major contributors of the improvement in hepatic status<sub>.</sub> Thus, fitted linear regression models showed a variance of 53% (adj. R<sup>2</sup> = 0.53) in hepatic functionality (FLI), 16% (adj. R<sup>2</sup> = 0.16) in lipidomic metabolism (OWLiver<sup>®</sup>-test) and 34% (adj. R<sup>2</sup> = 0.34) in liver fat content (MRI). These results demonstrate that three different genetic scores can be useful for the personalized management of NAFLD, whose treatment must rely on specific dietary recommendations guided by the measurement of specific genetic biomarkers.https://www.mdpi.com/2075-4418/11/6/1083NAFLDgenetic risk scorefatty liver indexlipidomicmagnetic resonance imaging |
| spellingShingle | Nuria Perez-Diaz-del-Campo Jose I. Riezu-Boj Bertha Araceli Marin-Alejandre J. Ignacio Monreal Mariana Elorz José Ignacio Herrero Alberto Benito-Boillos Fermín I. Milagro Josep A. Tur Itziar Abete M. Angeles Zulet J. Alfredo Martinez Three Different Genetic Risk Scores Based on Fatty Liver Index, Magnetic Resonance Imaging and Lipidomic for a Nutrigenetic Personalized Management of NAFLD: The Fatty Liver in Obesity Study Diagnostics NAFLD genetic risk score fatty liver index lipidomic magnetic resonance imaging |
| title | Three Different Genetic Risk Scores Based on Fatty Liver Index, Magnetic Resonance Imaging and Lipidomic for a Nutrigenetic Personalized Management of NAFLD: The Fatty Liver in Obesity Study |
| title_full | Three Different Genetic Risk Scores Based on Fatty Liver Index, Magnetic Resonance Imaging and Lipidomic for a Nutrigenetic Personalized Management of NAFLD: The Fatty Liver in Obesity Study |
| title_fullStr | Three Different Genetic Risk Scores Based on Fatty Liver Index, Magnetic Resonance Imaging and Lipidomic for a Nutrigenetic Personalized Management of NAFLD: The Fatty Liver in Obesity Study |
| title_full_unstemmed | Three Different Genetic Risk Scores Based on Fatty Liver Index, Magnetic Resonance Imaging and Lipidomic for a Nutrigenetic Personalized Management of NAFLD: The Fatty Liver in Obesity Study |
| title_short | Three Different Genetic Risk Scores Based on Fatty Liver Index, Magnetic Resonance Imaging and Lipidomic for a Nutrigenetic Personalized Management of NAFLD: The Fatty Liver in Obesity Study |
| title_sort | three different genetic risk scores based on fatty liver index magnetic resonance imaging and lipidomic for a nutrigenetic personalized management of nafld the fatty liver in obesity study |
| topic | NAFLD genetic risk score fatty liver index lipidomic magnetic resonance imaging |
| url | https://www.mdpi.com/2075-4418/11/6/1083 |
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