Retrospective analysis of clinical characteristics of 405 patients with COVID-19
Objective This study was performed to investigate the clinical characteristics of patients with coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods We analyzed the electronic medical records of 405 hospitalized patients with l...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-08-01
|
| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060520949039 |
| _version_ | 1818841743023407104 |
|---|---|
| author | Ting Zhan Meng Liu Yalin Tang Zheng Han Xueting Cheng Junsheng Deng Xiaoli Chen Xia Tian Xiaodong Huang |
| author_facet | Ting Zhan Meng Liu Yalin Tang Zheng Han Xueting Cheng Junsheng Deng Xiaoli Chen Xia Tian Xiaodong Huang |
| author_sort | Ting Zhan |
| collection | DOAJ |
| description | Objective This study was performed to investigate the clinical characteristics of patients with coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods We analyzed the electronic medical records of 405 hospitalized patients with laboratory-confirmed COVID-19 in the Third Hospital of Wuhan. Results The patients’ median age was 56 years, 54.1% were female, 11.4% had a history of smoking, and 10.6% had a history of drinking. All cases of COVID-19 were community-acquired. Fever (76.8%) and cough (53.3%) were the most common clinical manifestations, and circulatory system diseases were the most common comorbidities. Gastrointestinal symptoms were present in 61.2% of the patients, and 2.9% of the patients were asymptomatic. Computed tomography showed ground-glass opacities in most patients (72.6%) and consolidation in 30.9%. Lymphopenia (72.3%) and hypoproteinemia (71.6%) were observed in most patients. About 20% of patients had abnormal liver function. Patients with severe disease had significantly more prominent laboratory abnormalities, including an abnormal lymphocyte count and abnormal C-reactive protein, procalcitonin, alanine aminotransferase, aspartate aminotransferase, D-dimer, and albumin levels. Conclusion SARS-CoV-2 causes a variety of severe respiratory illnesses similar to those caused by SARS-CoV-1. Older age, chronic comorbidities, and laboratory abnormalities are associated with disease severity. |
| first_indexed | 2024-12-19T04:30:55Z |
| format | Article |
| id | doaj.art-f9df857b6fc44c82868450f2e0f2ef05 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-19T04:30:55Z |
| publishDate | 2020-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-f9df857b6fc44c82868450f2e0f2ef052022-12-21T20:35:53ZengSAGE PublishingJournal of International Medical Research1473-23002020-08-014810.1177/0300060520949039Retrospective analysis of clinical characteristics of 405 patients with COVID-19Ting ZhanMeng LiuYalin TangZheng HanXueting ChengJunsheng DengXiaoli ChenXia TianXiaodong HuangObjective This study was performed to investigate the clinical characteristics of patients with coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods We analyzed the electronic medical records of 405 hospitalized patients with laboratory-confirmed COVID-19 in the Third Hospital of Wuhan. Results The patients’ median age was 56 years, 54.1% were female, 11.4% had a history of smoking, and 10.6% had a history of drinking. All cases of COVID-19 were community-acquired. Fever (76.8%) and cough (53.3%) were the most common clinical manifestations, and circulatory system diseases were the most common comorbidities. Gastrointestinal symptoms were present in 61.2% of the patients, and 2.9% of the patients were asymptomatic. Computed tomography showed ground-glass opacities in most patients (72.6%) and consolidation in 30.9%. Lymphopenia (72.3%) and hypoproteinemia (71.6%) were observed in most patients. About 20% of patients had abnormal liver function. Patients with severe disease had significantly more prominent laboratory abnormalities, including an abnormal lymphocyte count and abnormal C-reactive protein, procalcitonin, alanine aminotransferase, aspartate aminotransferase, D-dimer, and albumin levels. Conclusion SARS-CoV-2 causes a variety of severe respiratory illnesses similar to those caused by SARS-CoV-1. Older age, chronic comorbidities, and laboratory abnormalities are associated with disease severity.https://doi.org/10.1177/0300060520949039 |
| spellingShingle | Ting Zhan Meng Liu Yalin Tang Zheng Han Xueting Cheng Junsheng Deng Xiaoli Chen Xia Tian Xiaodong Huang Retrospective analysis of clinical characteristics of 405 patients with COVID-19 Journal of International Medical Research |
| title | Retrospective analysis of clinical characteristics of 405 patients with COVID-19 |
| title_full | Retrospective analysis of clinical characteristics of 405 patients with COVID-19 |
| title_fullStr | Retrospective analysis of clinical characteristics of 405 patients with COVID-19 |
| title_full_unstemmed | Retrospective analysis of clinical characteristics of 405 patients with COVID-19 |
| title_short | Retrospective analysis of clinical characteristics of 405 patients with COVID-19 |
| title_sort | retrospective analysis of clinical characteristics of 405 patients with covid 19 |
| url | https://doi.org/10.1177/0300060520949039 |
| work_keys_str_mv | AT tingzhan retrospectiveanalysisofclinicalcharacteristicsof405patientswithcovid19 AT mengliu retrospectiveanalysisofclinicalcharacteristicsof405patientswithcovid19 AT yalintang retrospectiveanalysisofclinicalcharacteristicsof405patientswithcovid19 AT zhenghan retrospectiveanalysisofclinicalcharacteristicsof405patientswithcovid19 AT xuetingcheng retrospectiveanalysisofclinicalcharacteristicsof405patientswithcovid19 AT junshengdeng retrospectiveanalysisofclinicalcharacteristicsof405patientswithcovid19 AT xiaolichen retrospectiveanalysisofclinicalcharacteristicsof405patientswithcovid19 AT xiatian retrospectiveanalysisofclinicalcharacteristicsof405patientswithcovid19 AT xiaodonghuang retrospectiveanalysisofclinicalcharacteristicsof405patientswithcovid19 |