Impact of Moringa oleifera leaf extract in reducing the effect of lead acetate toxicity in mice
This study aimed to assess the impact of Moringa oleifera (M. oleifera) leaf extract against the poisoning of lead acetate; therefore, sixty mice were allocated into 4 groups with 15 in each, as G1) blank control, G2) supplied with 300 mg/kg body weight (BWT). M. oleifera extract, G3) supplied with...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Saudi Journal of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319562X22004235 |
| _version_ | 1811177654991192064 |
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| author | Sahar J. Melebary Moustafa H.R. Elnaggar |
| author_facet | Sahar J. Melebary Moustafa H.R. Elnaggar |
| author_sort | Sahar J. Melebary |
| collection | DOAJ |
| description | This study aimed to assess the impact of Moringa oleifera (M. oleifera) leaf extract against the poisoning of lead acetate; therefore, sixty mice were allocated into 4 groups with 15 in each, as G1) blank control, G2) supplied with 300 mg/kg body weight (BWT). M. oleifera extract, G3) supplied with 60 mg/kg BWT of lead acetate [Pb(C2H3O2)2], and G4) supplied with extract of M. oleifera + lead acetate. The liver enzymes were elevated post-treatment with Pb(C2H3O2)2, which then lowered to almost the normal level when M. oleifera was supplied to mice previously treated with Pb(C2H3O2)2. The values in (G3) decreased when compared with G1 (92.33 ± 12.99, 21.67 ± 2.91 and 98.00 ± 13.20 U/L, respectively. Also, the cholesterol and low-density lipoprotein levels were elevated post-supplementation with M. oleifera and Pb(C2H3O2)2. Pb(C2H3O2)2 improves the lipid profile, whereas M. oleifera pretreatment reduced cholesterol (CHOL), high density low cholesterol (HDL-c), and low-density low cholesterol (LDL-c) levels in animals fed Pb(C2H3O2)2. Pb(C2H3O2)2 elevates the total protein but lowers the total bilirubin and triglycerides post M. oleifera treatment and Pb(C2H3O2)2 when contrasted with G1. The protective effect of M. oleifera was caused by the fact that it lowered triglycerides (TG) and total bilirubin (TBIL) and raised total protein (TP). After administration of Pb(C2H3O2)2, the histological examination revealed alterations in the hepatocytes and kidneys of G3. Also, the liver and kidney cells in mice supplied with M. oleifera after Pb(C2H3O2)2 poisoning recovered. In conclusion, Pb is toxic, and the usage of M. oleifera partially enhances the negative impacts induced by Pb(C2H3O2)2. |
| first_indexed | 2024-04-11T06:05:55Z |
| format | Article |
| id | doaj.art-f9e2bb1291a74c2190b754e67e4e112b |
| institution | Directory Open Access Journal |
| issn | 1319-562X |
| language | English |
| last_indexed | 2024-04-11T06:05:55Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Journal of Biological Sciences |
| spelling | doaj.art-f9e2bb1291a74c2190b754e67e4e112b2022-12-22T04:41:31ZengElsevierSaudi Journal of Biological Sciences1319-562X2023-01-01301103507Impact of Moringa oleifera leaf extract in reducing the effect of lead acetate toxicity in miceSahar J. Melebary0Moustafa H.R. Elnaggar1Department of Biology, College of Science, University of Jeddah, Jeddah 21493, Saudi Arabia; Corresponding author.Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; Zoology Department, Faculty of Science, Suez Canal University, Ismailia, EgyptThis study aimed to assess the impact of Moringa oleifera (M. oleifera) leaf extract against the poisoning of lead acetate; therefore, sixty mice were allocated into 4 groups with 15 in each, as G1) blank control, G2) supplied with 300 mg/kg body weight (BWT). M. oleifera extract, G3) supplied with 60 mg/kg BWT of lead acetate [Pb(C2H3O2)2], and G4) supplied with extract of M. oleifera + lead acetate. The liver enzymes were elevated post-treatment with Pb(C2H3O2)2, which then lowered to almost the normal level when M. oleifera was supplied to mice previously treated with Pb(C2H3O2)2. The values in (G3) decreased when compared with G1 (92.33 ± 12.99, 21.67 ± 2.91 and 98.00 ± 13.20 U/L, respectively. Also, the cholesterol and low-density lipoprotein levels were elevated post-supplementation with M. oleifera and Pb(C2H3O2)2. Pb(C2H3O2)2 improves the lipid profile, whereas M. oleifera pretreatment reduced cholesterol (CHOL), high density low cholesterol (HDL-c), and low-density low cholesterol (LDL-c) levels in animals fed Pb(C2H3O2)2. Pb(C2H3O2)2 elevates the total protein but lowers the total bilirubin and triglycerides post M. oleifera treatment and Pb(C2H3O2)2 when contrasted with G1. The protective effect of M. oleifera was caused by the fact that it lowered triglycerides (TG) and total bilirubin (TBIL) and raised total protein (TP). After administration of Pb(C2H3O2)2, the histological examination revealed alterations in the hepatocytes and kidneys of G3. Also, the liver and kidney cells in mice supplied with M. oleifera after Pb(C2H3O2)2 poisoning recovered. In conclusion, Pb is toxic, and the usage of M. oleifera partially enhances the negative impacts induced by Pb(C2H3O2)2.http://www.sciencedirect.com/science/article/pii/S1319562X22004235Blood chemistryHistopathologyLead acetateMoringa oleiferaMiceToxicity |
| spellingShingle | Sahar J. Melebary Moustafa H.R. Elnaggar Impact of Moringa oleifera leaf extract in reducing the effect of lead acetate toxicity in mice Saudi Journal of Biological Sciences Blood chemistry Histopathology Lead acetate Moringa oleifera Mice Toxicity |
| title | Impact of Moringa oleifera leaf extract in reducing the effect of lead acetate toxicity in mice |
| title_full | Impact of Moringa oleifera leaf extract in reducing the effect of lead acetate toxicity in mice |
| title_fullStr | Impact of Moringa oleifera leaf extract in reducing the effect of lead acetate toxicity in mice |
| title_full_unstemmed | Impact of Moringa oleifera leaf extract in reducing the effect of lead acetate toxicity in mice |
| title_short | Impact of Moringa oleifera leaf extract in reducing the effect of lead acetate toxicity in mice |
| title_sort | impact of moringa oleifera leaf extract in reducing the effect of lead acetate toxicity in mice |
| topic | Blood chemistry Histopathology Lead acetate Moringa oleifera Mice Toxicity |
| url | http://www.sciencedirect.com/science/article/pii/S1319562X22004235 |
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