The miR-145 rs353291 C allele increases susceptibility to atherosclerosis
Atherosclerosis (AS) is one of the leading causes of death, with variable frequencies in different populations. To this end, we examined whether AS is associated with the miR-145 rs353291 polymorphism and specific rs353291 alleles. The distribution of the rs353291 C allele and CC genotypes was signi...
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| Format: | Article |
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IMR Press
2020-01-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/25/3/10.2741/4822 |
| _version_ | 1818242717684072448 |
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| author | Yu Lv Yihu Yi Sujie Jia Xiangdong Peng Heng Yang Ren Guo |
| author_facet | Yu Lv Yihu Yi Sujie Jia Xiangdong Peng Heng Yang Ren Guo |
| author_sort | Yu Lv |
| collection | DOAJ |
| description | Atherosclerosis (AS) is one of the leading causes of death, with variable frequencies in different populations. To this end, we examined whether AS is associated with the miR-145 rs353291 polymorphism and specific rs353291 alleles. The distribution of the rs353291 C allele and CC genotypes was significantly higher in AS patients than in controls. Compared to individuals with the rs353291 TT genotype, carriers of the rs353291 C allele showed a significant increase in the plasma levels of sCD40L, IL-6 and MCP-1 and a decrease in miR-145 expression. After ox-LDL administration, the peripheral blood mononuclear cells (PBMCs) of rs353291 C allele carriers showed significantly increased CD40 and MCP-1 expression compared with those of individuals with the rs353291 TT genotype. These data suggest that the rs353291 C allele may increase susceptibility to atherosclerosis. |
| first_indexed | 2024-12-12T13:49:40Z |
| format | Article |
| id | doaj.art-f9e2e9f273a345f8a075427b59257359 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-12-12T13:49:40Z |
| publishDate | 2020-01-01 |
| publisher | IMR Press |
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| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-f9e2e9f273a345f8a075427b592573592022-12-22T00:22:36ZengIMR PressFrontiers in Bioscience-Landmark2768-67012020-01-0125357759210.2741/4822FBS-25-577The miR-145 rs353291 C allele increases susceptibility to atherosclerosisYu Lv0Yihu Yi1Sujie Jia2Xiangdong Peng3Heng Yang4Ren Guo5Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. ChinaXiangya School of Medical Science of Central South University, Changsha, Hunan 410013, P.R. ChinaDepartment of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. ChinaDepartment of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. ChinaDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. ChinaDepartment of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. ChinaAtherosclerosis (AS) is one of the leading causes of death, with variable frequencies in different populations. To this end, we examined whether AS is associated with the miR-145 rs353291 polymorphism and specific rs353291 alleles. The distribution of the rs353291 C allele and CC genotypes was significantly higher in AS patients than in controls. Compared to individuals with the rs353291 TT genotype, carriers of the rs353291 C allele showed a significant increase in the plasma levels of sCD40L, IL-6 and MCP-1 and a decrease in miR-145 expression. After ox-LDL administration, the peripheral blood mononuclear cells (PBMCs) of rs353291 C allele carriers showed significantly increased CD40 and MCP-1 expression compared with those of individuals with the rs353291 TT genotype. These data suggest that the rs353291 C allele may increase susceptibility to atherosclerosis.https://www.imrpress.com/journal/FBL/25/3/10.2741/4822atherosclerosismir-145cd40il-6mcp-1 |
| spellingShingle | Yu Lv Yihu Yi Sujie Jia Xiangdong Peng Heng Yang Ren Guo The miR-145 rs353291 C allele increases susceptibility to atherosclerosis Frontiers in Bioscience-Landmark atherosclerosis mir-145 cd40 il-6 mcp-1 |
| title | The miR-145 rs353291 C allele increases susceptibility to atherosclerosis |
| title_full | The miR-145 rs353291 C allele increases susceptibility to atherosclerosis |
| title_fullStr | The miR-145 rs353291 C allele increases susceptibility to atherosclerosis |
| title_full_unstemmed | The miR-145 rs353291 C allele increases susceptibility to atherosclerosis |
| title_short | The miR-145 rs353291 C allele increases susceptibility to atherosclerosis |
| title_sort | mir 145 rs353291 c allele increases susceptibility to atherosclerosis |
| topic | atherosclerosis mir-145 cd40 il-6 mcp-1 |
| url | https://www.imrpress.com/journal/FBL/25/3/10.2741/4822 |
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