Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour
Astrocytes may contribute to synaptic remodelling in the cortex in chronic pain states. Here the authors describe modulation of astrocyte activity to drive circuit reorganization in somatosensory cortex in mice, along with peripheral nerve block, which could be a potential therapeutic approach for t...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31773-8 |
| _version_ | 1818198359639326720 |
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| author | Ikuko Takeda Kohei Yoshihara Dennis L. Cheung Tomoko Kobayashi Masakazu Agetsuma Makoto Tsuda Kei Eto Schuichi Koizumi Hiroaki Wake Andrew J. Moorhouse Junichi Nabekura |
| author_facet | Ikuko Takeda Kohei Yoshihara Dennis L. Cheung Tomoko Kobayashi Masakazu Agetsuma Makoto Tsuda Kei Eto Schuichi Koizumi Hiroaki Wake Andrew J. Moorhouse Junichi Nabekura |
| author_sort | Ikuko Takeda |
| collection | DOAJ |
| description | Astrocytes may contribute to synaptic remodelling in the cortex in chronic pain states. Here the authors describe modulation of astrocyte activity to drive circuit reorganization in somatosensory cortex in mice, along with peripheral nerve block, which could be a potential therapeutic approach for the treatment of chronic pain. |
| first_indexed | 2024-12-12T02:04:37Z |
| format | Article |
| id | doaj.art-f9e5b2155e06424d8556f494c3f4191f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T02:04:37Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f9e5b2155e06424d8556f494c3f4191f2022-12-22T00:42:06ZengNature PortfolioNature Communications2041-17232022-07-0113111210.1038/s41467-022-31773-8Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviourIkuko Takeda0Kohei Yoshihara1Dennis L. Cheung2Tomoko Kobayashi3Masakazu Agetsuma4Makoto Tsuda5Kei Eto6Schuichi Koizumi7Hiroaki Wake8Andrew J. Moorhouse9Junichi Nabekura10Division of Homeostatic Development, National Institute for Physiological SciencesDepartment of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu UniversityDivision of Homeostatic Development, National Institute for Physiological SciencesDivision of Homeostatic Development, National Institute for Physiological SciencesDivision of Homeostatic Development, National Institute for Physiological SciencesDepartment of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu UniversityDivision of Homeostatic Development, National Institute for Physiological SciencesDepartment of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of YamanashiDepartment of Anatomy and Molecular Cell Biology Graduate School of Medicine, Nagoya UniversityDepartment of Physiology, School of Medical Sciences, The University of New South WalesDivision of Homeostatic Development, National Institute for Physiological SciencesAstrocytes may contribute to synaptic remodelling in the cortex in chronic pain states. Here the authors describe modulation of astrocyte activity to drive circuit reorganization in somatosensory cortex in mice, along with peripheral nerve block, which could be a potential therapeutic approach for the treatment of chronic pain.https://doi.org/10.1038/s41467-022-31773-8 |
| spellingShingle | Ikuko Takeda Kohei Yoshihara Dennis L. Cheung Tomoko Kobayashi Masakazu Agetsuma Makoto Tsuda Kei Eto Schuichi Koizumi Hiroaki Wake Andrew J. Moorhouse Junichi Nabekura Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour Nature Communications |
| title | Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour |
| title_full | Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour |
| title_fullStr | Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour |
| title_full_unstemmed | Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour |
| title_short | Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour |
| title_sort | controlled activation of cortical astrocytes modulates neuropathic pain like behaviour |
| url | https://doi.org/10.1038/s41467-022-31773-8 |
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