Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour
Astrocytes may contribute to synaptic remodelling in the cortex in chronic pain states. Here the authors describe modulation of astrocyte activity to drive circuit reorganization in somatosensory cortex in mice, along with peripheral nerve block, which could be a potential therapeutic approach for t...
Main Authors: | Ikuko Takeda, Kohei Yoshihara, Dennis L. Cheung, Tomoko Kobayashi, Masakazu Agetsuma, Makoto Tsuda, Kei Eto, Schuichi Koizumi, Hiroaki Wake, Andrew J. Moorhouse, Junichi Nabekura |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-07-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-31773-8 |
Similar Items
-
Goshajinkigan attenuates paclitaxel‐induced neuropathic pain via cortical astrocytes
by: Kenta Takanashi, et al.
Published: (2021-12-01) -
The astrocyte-targeted therapy by Bushi for the neuropathic pain in mice.
by: Keisuke Shibata, et al.
Published: (2011-01-01) -
Abnormal Ca<sup>2+</sup> Signals in Reactive Astrocytes as a Common Cause of Brain Diseases
by: Schuichi Koizumi, et al.
Published: (2021-12-01) -
KCC2 downregulation after sciatic nerve injury enhances motor function recovery
by: Dennis Lawrence Cheung, et al.
Published: (2023-05-01) -
Potential roles of astrocytes and Müller cells in the pathogenesis of glaucoma
by: Youichi Shinozaki, et al.
Published: (2021-03-01)