Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging
Previous work showed that the caspase 1 inhibitor VX-765 rescued cognitive deficits in the J20 mouse model of Alzheimer’s disease, and this may occur via reduced inflammation. Here the authors show that administration of the drug prior to onset of cognitive deficits and pathology in mice delays the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18405-9 |
| _version_ | 1818434128755818496 |
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| author | Joseph Flores Anastasia Noël Bénédicte Foveau Olivier Beauchet Andréa C. LeBlanc |
| author_facet | Joseph Flores Anastasia Noël Bénédicte Foveau Olivier Beauchet Andréa C. LeBlanc |
| author_sort | Joseph Flores |
| collection | DOAJ |
| description | Previous work showed that the caspase 1 inhibitor VX-765 rescued cognitive deficits in the J20 mouse model of Alzheimer’s disease, and this may occur via reduced inflammation. Here the authors show that administration of the drug prior to onset of cognitive deficits and pathology in mice delays the onset of deficits. |
| first_indexed | 2024-12-14T16:32:04Z |
| format | Article |
| id | doaj.art-f9e708e8e4a94657bdc8e388bc81fd42 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:32:04Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f9e708e8e4a94657bdc8e388bc81fd422022-12-21T22:54:33ZengNature PortfolioNature Communications2041-17232020-09-0111111410.1038/s41467-020-18405-9Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and agingJoseph Flores0Anastasia Noël1Bénédicte Foveau2Olivier Beauchet3Andréa C. LeBlanc4Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General HospitalBloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General HospitalBloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General HospitalBloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General HospitalBloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General HospitalPrevious work showed that the caspase 1 inhibitor VX-765 rescued cognitive deficits in the J20 mouse model of Alzheimer’s disease, and this may occur via reduced inflammation. Here the authors show that administration of the drug prior to onset of cognitive deficits and pathology in mice delays the onset of deficits.https://doi.org/10.1038/s41467-020-18405-9 |
| spellingShingle | Joseph Flores Anastasia Noël Bénédicte Foveau Olivier Beauchet Andréa C. LeBlanc Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging Nature Communications |
| title | Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging |
| title_full | Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging |
| title_fullStr | Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging |
| title_full_unstemmed | Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging |
| title_short | Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging |
| title_sort | pre symptomatic caspase 1 inhibitor delays cognitive decline in a mouse model of alzheimer disease and aging |
| url | https://doi.org/10.1038/s41467-020-18405-9 |
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