Impact of Aβ40 and Aβ42 Fibrils on the Transcriptome of Primary Astrocytes and Microglia

Impact of Aβ40 and Aβ42 Fibrils on the Transcriptome of Primary Astrocytes and Microglia

Fibrillar amyloid β-protein (Aβ) deposits in the brain, which are primarily composed of Aβ40 or Aβ42 peptides, are key pathological features of Alzheimer’s disease (AD) and related disorders. Although the underlying mechanisms are still not clear, the Aβ fibrils can trigger a number of cellular resp...

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Bibliographic Details
Main Authors: Xiaoyue Zhu, Joseph M. Schrader, Brandon A. Irizarry, Steven O. Smith, William E. Van Nostrand
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomedicines
Subjects:
amyloid β-protein
fibrils
astrocytes
microglia
RNA sequencing
Online Access:https://www.mdpi.com/2227-9059/10/11/2982

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