Paclitaxel induces cognitive impairment via necroptosis, decreased synaptic plasticity and M1 polarisation of microglia

Paclitaxel induces cognitive impairment via necroptosis, decreased synaptic plasticity and M1 polarisation of microglia

Context Paclitaxel (PTX) leads to chemotherapy brain (chemo-brain) which is characterised by cognitive impairment. It has been reported that necroptosis is associated with cognitive impairment in some neurodegenerative diseases, but it is not clear whether it is related to the development of chemo-b...

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Bibliographic Details
Main Authors: Miao Tang, Shuang Zhao, Jia-Xin Liu, Xin Liu, Yue-Xian Guo, Gui-Ying Wang, Xiu-Li Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Pharmaceutical Biology
Subjects:
Central neurotoxicity
hippocampus
neuron
astrocytes
inflammatory factors
Online Access:https://www.tandfonline.com/doi/10.1080/13880209.2022.2108064

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