Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease
Neutrophils are versatile innate effector cells essential for immune defense but also responsible for pathologic inflammation. This dual role complicates therapeutic targeting. However, neither neutrophils themselves nor the mechanisms they employ in different forms of immune responses are homogeneo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00346/full |
| _version_ | 1828275417001230336 |
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| author | Ricardo Grieshaber-Bouyer Peter A. Nigrovic Peter A. Nigrovic |
| author_facet | Ricardo Grieshaber-Bouyer Peter A. Nigrovic Peter A. Nigrovic |
| author_sort | Ricardo Grieshaber-Bouyer |
| collection | DOAJ |
| description | Neutrophils are versatile innate effector cells essential for immune defense but also responsible for pathologic inflammation. This dual role complicates therapeutic targeting. However, neither neutrophils themselves nor the mechanisms they employ in different forms of immune responses are homogeneous, offering possibilities for selective intervention. Here we review heterogeneity within the neutrophil population as well as in the pathways mediating neutrophil recruitment to inflamed tissues with a view to outlining opportunities for therapeutic manipulation in inflammatory disease. |
| first_indexed | 2024-04-13T06:48:05Z |
| format | Article |
| id | doaj.art-f9e7ea3c65f549df82a572f927a6ca7c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T06:48:05Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f9e7ea3c65f549df82a572f927a6ca7c2022-12-22T02:57:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-03-011010.3389/fimmu.2019.00346443160Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated DiseaseRicardo Grieshaber-Bouyer0Peter A. Nigrovic1Peter A. Nigrovic2Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, United StatesDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, United StatesDivision of Immunology, Boston Children's Hospital, Boston, MA, United StatesNeutrophils are versatile innate effector cells essential for immune defense but also responsible for pathologic inflammation. This dual role complicates therapeutic targeting. However, neither neutrophils themselves nor the mechanisms they employ in different forms of immune responses are homogeneous, offering possibilities for selective intervention. Here we review heterogeneity within the neutrophil population as well as in the pathways mediating neutrophil recruitment to inflamed tissues with a view to outlining opportunities for therapeutic manipulation in inflammatory disease.https://www.frontiersin.org/article/10.3389/fimmu.2019.00346/fullneutrophilimmune mediated diseasetherapeutic opportunitiesgranulopoiesisneutrophil migrationCD177 |
| spellingShingle | Ricardo Grieshaber-Bouyer Peter A. Nigrovic Peter A. Nigrovic Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease Frontiers in Immunology neutrophil immune mediated disease therapeutic opportunities granulopoiesis neutrophil migration CD177 |
| title | Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease |
| title_full | Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease |
| title_fullStr | Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease |
| title_full_unstemmed | Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease |
| title_short | Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease |
| title_sort | neutrophil heterogeneity as therapeutic opportunity in immune mediated disease |
| topic | neutrophil immune mediated disease therapeutic opportunities granulopoiesis neutrophil migration CD177 |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.00346/full |
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