Next-Generation Nanomedicine Approaches for the Management of Retinal Diseases
Retinal diseases are one of the leading causes of blindness globally. The mainstay treatments for these blinding diseases are laser photocoagulation, vitrectomy, and repeated intravitreal injections of anti-vascular endothelial growth factor (VEGF) or steroids. Unfortunately, these therapies are ass...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/7/2005 |
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| author | Binapani Mahaling Shermaine W. Y. Low Sanjay Ch Utkarsh R. Addi Baseer Ahmad Thomas B. Connor Rajiv R. Mohan Swati Biswas Shyam S. Chaurasia |
| author_facet | Binapani Mahaling Shermaine W. Y. Low Sanjay Ch Utkarsh R. Addi Baseer Ahmad Thomas B. Connor Rajiv R. Mohan Swati Biswas Shyam S. Chaurasia |
| author_sort | Binapani Mahaling |
| collection | DOAJ |
| description | Retinal diseases are one of the leading causes of blindness globally. The mainstay treatments for these blinding diseases are laser photocoagulation, vitrectomy, and repeated intravitreal injections of anti-vascular endothelial growth factor (VEGF) or steroids. Unfortunately, these therapies are associated with ocular complications like inflammation, elevated intraocular pressure, retinal detachment, endophthalmitis, and vitreous hemorrhage. Recent advances in nanomedicine seek to curtail these limitations, overcoming ocular barriers by developing non-invasive or minimally invasive delivery modalities. These modalities include delivering therapeutics to specific cellular targets in the retina, providing sustained delivery of drugs to avoid repeated intravitreal injections, and acting as a scaffold for neural tissue regeneration. These next-generation nanomedicine approaches could potentially revolutionize the treatment landscape of retinal diseases. This review describes the availability and limitations of current treatment strategies and highlights insights into the advancement of future approaches using next-generation nanomedicines to manage retinal diseases. |
| first_indexed | 2024-03-11T00:44:29Z |
| format | Article |
| id | doaj.art-f9e8af99070c4369a9c133dc2d11646e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T00:44:29Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-f9e8af99070c4369a9c133dc2d11646e2023-11-18T20:56:51ZengMDPI AGPharmaceutics1999-49232023-07-01157200510.3390/pharmaceutics15072005Next-Generation Nanomedicine Approaches for the Management of Retinal DiseasesBinapani Mahaling0Shermaine W. Y. Low1Sanjay Ch2Utkarsh R. Addi3Baseer Ahmad4Thomas B. Connor5Rajiv R. Mohan6Swati Biswas7Shyam S. Chaurasia8Ocular Immunology and Angiogenesis Lab, Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USAOcular Immunology and Angiogenesis Lab, Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USANanomedicine Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad 500078, IndiaOcular Immunology and Angiogenesis Lab, Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USAOcular Immunology and Angiogenesis Lab, Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USAOcular Immunology and Angiogenesis Lab, Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USAOne-Health One-Medicine Ophthalmology and Vision Research Program, University of Missouri, Columbia, MO 65211, USANanomedicine Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad 500078, IndiaOcular Immunology and Angiogenesis Lab, Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USARetinal diseases are one of the leading causes of blindness globally. The mainstay treatments for these blinding diseases are laser photocoagulation, vitrectomy, and repeated intravitreal injections of anti-vascular endothelial growth factor (VEGF) or steroids. Unfortunately, these therapies are associated with ocular complications like inflammation, elevated intraocular pressure, retinal detachment, endophthalmitis, and vitreous hemorrhage. Recent advances in nanomedicine seek to curtail these limitations, overcoming ocular barriers by developing non-invasive or minimally invasive delivery modalities. These modalities include delivering therapeutics to specific cellular targets in the retina, providing sustained delivery of drugs to avoid repeated intravitreal injections, and acting as a scaffold for neural tissue regeneration. These next-generation nanomedicine approaches could potentially revolutionize the treatment landscape of retinal diseases. This review describes the availability and limitations of current treatment strategies and highlights insights into the advancement of future approaches using next-generation nanomedicines to manage retinal diseases.https://www.mdpi.com/1999-4923/15/7/2005nanomedicinesretinananoparticlesnanostructured scaffoldsnanodevicesnanodelivery |
| spellingShingle | Binapani Mahaling Shermaine W. Y. Low Sanjay Ch Utkarsh R. Addi Baseer Ahmad Thomas B. Connor Rajiv R. Mohan Swati Biswas Shyam S. Chaurasia Next-Generation Nanomedicine Approaches for the Management of Retinal Diseases Pharmaceutics nanomedicines retina nanoparticles nanostructured scaffolds nanodevices nanodelivery |
| title | Next-Generation Nanomedicine Approaches for the Management of Retinal Diseases |
| title_full | Next-Generation Nanomedicine Approaches for the Management of Retinal Diseases |
| title_fullStr | Next-Generation Nanomedicine Approaches for the Management of Retinal Diseases |
| title_full_unstemmed | Next-Generation Nanomedicine Approaches for the Management of Retinal Diseases |
| title_short | Next-Generation Nanomedicine Approaches for the Management of Retinal Diseases |
| title_sort | next generation nanomedicine approaches for the management of retinal diseases |
| topic | nanomedicines retina nanoparticles nanostructured scaffolds nanodevices nanodelivery |
| url | https://www.mdpi.com/1999-4923/15/7/2005 |
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