Morphometric development of the human fetal cerebellum during the early second trimester
The protracted nature of development makes the cerebellum vulnerable to a broad spectrum of pathologic conditions, especially during the early fetal period. This study aims to characterize normal cerebellar growth in human fetuses during the early second trimester. We manually segmented the fetal ce...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-02-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811919309632 |
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| author | Feifei Xu Xinting Ge Yonggang Shi Zhonghe Zhang Yuchun Tang Xiangtao Lin Gaojun Teng Fengchao Zang Nuonan Gao Haihong Liu Arthur W. Toga Shuwei Liu |
| author_facet | Feifei Xu Xinting Ge Yonggang Shi Zhonghe Zhang Yuchun Tang Xiangtao Lin Gaojun Teng Fengchao Zang Nuonan Gao Haihong Liu Arthur W. Toga Shuwei Liu |
| author_sort | Feifei Xu |
| collection | DOAJ |
| description | The protracted nature of development makes the cerebellum vulnerable to a broad spectrum of pathologic conditions, especially during the early fetal period. This study aims to characterize normal cerebellar growth in human fetuses during the early second trimester. We manually segmented the fetal cerebellum using 7.0-T high-resolution MR images obtained in 35 specimens with gestational ages ranging from 15 to 22 weeks. Volume measurements and shape analysis were performed to quantitatively evaluate global and regional cerebellar growth. The absolute volume of the fetal cerebellum showed a quadratic growth with increasing gestational age, while the pattern of relative volume changes revealed that the cerebellum grew at a greater pace than the cerebrum after 17 gestational weeks. Shape analysis was used to examine the distinctive development of subregions of the cerebellum. The extreme lateral portions of both cerebellar hemispheres showed the lowest rate of growth. The anterior lobe grew faster than most of the posterior lobe. These findings expand our understanding of the early growth pattern of the human cerebellum and could be further used to assess the developmental conditions of the fetal brain. |
| first_indexed | 2024-04-12T03:41:36Z |
| format | Article |
| id | doaj.art-f9ec0ecadf1a4d88b443c857b2da964d |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-12T03:41:36Z |
| publishDate | 2020-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-f9ec0ecadf1a4d88b443c857b2da964d2022-12-22T03:49:16ZengElsevierNeuroImage1095-95722020-02-01207116372Morphometric development of the human fetal cerebellum during the early second trimesterFeifei Xu0Xinting Ge1Yonggang Shi2Zhonghe Zhang3Yuchun Tang4Xiangtao Lin5Gaojun Teng6Fengchao Zang7Nuonan Gao8Haihong Liu9Arthur W. Toga10Shuwei Liu11Research Center for Sectional and Imaging Anatomy, Shandong University Cheeloo College of Medicine, 250012, Jinan, Shandong, China; Laboratory of Neuro Imaging (LONI), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, 90033, USADepartment of Medical Imaging, Xuzhou Medical University, 221004, Xuzhou, Jiangsu, China; Laboratory of Neuro Imaging (LONI), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, 90033, USALaboratory of Neuro Imaging (LONI), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, 90033, USAResearch Center for Sectional and Imaging Anatomy, Shandong University Cheeloo College of Medicine, 250012, Jinan, Shandong, China; Department of Medical Imaging, Provincial Hospital Affiliated to Shandong University, 250021, Jinan, Shandong, ChinaResearch Center for Sectional and Imaging Anatomy, Shandong University Cheeloo College of Medicine, 250012, Jinan, Shandong, ChinaResearch Center for Sectional and Imaging Anatomy, Shandong University Cheeloo College of Medicine, 250012, Jinan, Shandong, China; Department of Medical Imaging, Provincial Hospital Affiliated to Shandong University, 250021, Jinan, Shandong, ChinaDepartment of Radiology, Zhong Da Hospital, Southeast University School of Clinical Medicine, 210009, Nanjing, Jiangsu, ChinaDepartment of Radiology, Zhong Da Hospital, Southeast University School of Clinical Medicine, 210009, Nanjing, Jiangsu, ChinaNanjing First Hospital, Affiliated to Nanjing Medical University, 210006, Nanjing, Jiangsu, ChinaDepartment of Medical Imaging, Xuzhou Medical University, 221004, Xuzhou, Jiangsu, ChinaLaboratory of Neuro Imaging (LONI), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, 90033, USAResearch Center for Sectional and Imaging Anatomy, Shandong University Cheeloo College of Medicine, 250012, Jinan, Shandong, China; Corresponding author.The protracted nature of development makes the cerebellum vulnerable to a broad spectrum of pathologic conditions, especially during the early fetal period. This study aims to characterize normal cerebellar growth in human fetuses during the early second trimester. We manually segmented the fetal cerebellum using 7.0-T high-resolution MR images obtained in 35 specimens with gestational ages ranging from 15 to 22 weeks. Volume measurements and shape analysis were performed to quantitatively evaluate global and regional cerebellar growth. The absolute volume of the fetal cerebellum showed a quadratic growth with increasing gestational age, while the pattern of relative volume changes revealed that the cerebellum grew at a greater pace than the cerebrum after 17 gestational weeks. Shape analysis was used to examine the distinctive development of subregions of the cerebellum. The extreme lateral portions of both cerebellar hemispheres showed the lowest rate of growth. The anterior lobe grew faster than most of the posterior lobe. These findings expand our understanding of the early growth pattern of the human cerebellum and could be further used to assess the developmental conditions of the fetal brain.http://www.sciencedirect.com/science/article/pii/S1053811919309632High-resolution MRIFetal brain developmentCerebellumShape analysis |
| spellingShingle | Feifei Xu Xinting Ge Yonggang Shi Zhonghe Zhang Yuchun Tang Xiangtao Lin Gaojun Teng Fengchao Zang Nuonan Gao Haihong Liu Arthur W. Toga Shuwei Liu Morphometric development of the human fetal cerebellum during the early second trimester NeuroImage High-resolution MRI Fetal brain development Cerebellum Shape analysis |
| title | Morphometric development of the human fetal cerebellum during the early second trimester |
| title_full | Morphometric development of the human fetal cerebellum during the early second trimester |
| title_fullStr | Morphometric development of the human fetal cerebellum during the early second trimester |
| title_full_unstemmed | Morphometric development of the human fetal cerebellum during the early second trimester |
| title_short | Morphometric development of the human fetal cerebellum during the early second trimester |
| title_sort | morphometric development of the human fetal cerebellum during the early second trimester |
| topic | High-resolution MRI Fetal brain development Cerebellum Shape analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1053811919309632 |
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