CD36 maintains the gastric mucosa and associates with gastric disease
Jacome-Sosa et al. examine gastric function of CD36, reporting that CD36 knockout mice have altered gland organization and exhibit more fibronectin and inflammatory signaling. The authors find mucosal repair is abrogated due to defective epithelial cell renewal and progenitor cell differentiation, d...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02765-z |
| _version_ | 1818897314104737792 |
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| author | Miriam Jacome-Sosa Zhi-Feng Miao Vivek S. Peche Edward F. Morris Ramkumar Narendran Kathryn M. Pietka Dmitri Samovski Hei-Yong G. Lo Terri Pietka Andrea Varro Latisha Love-Gregory James R. Goldenring Ondrej Kuda Eric R. Gamazon Jason C. Mills Nada A. Abumrad |
| author_facet | Miriam Jacome-Sosa Zhi-Feng Miao Vivek S. Peche Edward F. Morris Ramkumar Narendran Kathryn M. Pietka Dmitri Samovski Hei-Yong G. Lo Terri Pietka Andrea Varro Latisha Love-Gregory James R. Goldenring Ondrej Kuda Eric R. Gamazon Jason C. Mills Nada A. Abumrad |
| author_sort | Miriam Jacome-Sosa |
| collection | DOAJ |
| description | Jacome-Sosa et al. examine gastric function of CD36, reporting that CD36 knockout mice have altered gland organization and exhibit more fibronectin and inflammatory signaling. The authors find mucosal repair is abrogated due to defective epithelial cell renewal and progenitor cell differentiation, due to reduced fatty acid delivery and altered lipid metabolism, and find associations between low CD36 expression and gastric diseases. |
| first_indexed | 2024-12-19T19:14:12Z |
| format | Article |
| id | doaj.art-f9ec101e1f814b5fab8d34541185e8f0 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-19T19:14:12Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-f9ec101e1f814b5fab8d34541185e8f02022-12-21T20:09:11ZengNature PortfolioCommunications Biology2399-36422021-11-014111510.1038/s42003-021-02765-zCD36 maintains the gastric mucosa and associates with gastric diseaseMiriam Jacome-Sosa0Zhi-Feng Miao1Vivek S. Peche2Edward F. Morris3Ramkumar Narendran4Kathryn M. Pietka5Dmitri Samovski6Hei-Yong G. Lo7Terri Pietka8Andrea Varro9Latisha Love-Gregory10James R. Goldenring11Ondrej Kuda12Eric R. Gamazon13Jason C. Mills14Nada A. Abumrad15Center for Human Nutrition, Department of Medicine, Washington University School of MedicineDepartment of Surgical Oncology, Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, First Hospital of China Medical UniversityCenter for Human Nutrition, Department of Medicine, Washington University School of MedicineCenter for Human Nutrition, Department of Medicine, Washington University School of MedicineCenter for Human Nutrition, Department of Medicine, Washington University School of MedicineCenter for Human Nutrition, Department of Medicine, Washington University School of MedicineCenter for Human Nutrition, Department of Medicine, Washington University School of MedicineDivision of Gastroenterology, Department of Medicine, Washington University School of MedicineCenter for Human Nutrition, Department of Medicine, Washington University School of MedicineInstitute of Translational Medicine, University of LiverpoolDepartment of Pathology & Immunology, Washington University School of MedicineDepartments of Surgery and Cell and Developmental Biology, Vanderbilt University Medical Center and VA Medical CenterInstitute of Physiology, Czech Academy of Sciences, Videnska 1083Division of Genetic Medicine, Vanderbilt University Medical CenterGastroenterology & Hepatology Section, Departments of Medicine and of Molecular and Cellular Biology, Baylor College of MedicineCenter for Human Nutrition, Department of Medicine, Washington University School of MedicineJacome-Sosa et al. examine gastric function of CD36, reporting that CD36 knockout mice have altered gland organization and exhibit more fibronectin and inflammatory signaling. The authors find mucosal repair is abrogated due to defective epithelial cell renewal and progenitor cell differentiation, due to reduced fatty acid delivery and altered lipid metabolism, and find associations between low CD36 expression and gastric diseases.https://doi.org/10.1038/s42003-021-02765-z |
| spellingShingle | Miriam Jacome-Sosa Zhi-Feng Miao Vivek S. Peche Edward F. Morris Ramkumar Narendran Kathryn M. Pietka Dmitri Samovski Hei-Yong G. Lo Terri Pietka Andrea Varro Latisha Love-Gregory James R. Goldenring Ondrej Kuda Eric R. Gamazon Jason C. Mills Nada A. Abumrad CD36 maintains the gastric mucosa and associates with gastric disease Communications Biology |
| title | CD36 maintains the gastric mucosa and associates with gastric disease |
| title_full | CD36 maintains the gastric mucosa and associates with gastric disease |
| title_fullStr | CD36 maintains the gastric mucosa and associates with gastric disease |
| title_full_unstemmed | CD36 maintains the gastric mucosa and associates with gastric disease |
| title_short | CD36 maintains the gastric mucosa and associates with gastric disease |
| title_sort | cd36 maintains the gastric mucosa and associates with gastric disease |
| url | https://doi.org/10.1038/s42003-021-02765-z |
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