Desenvolvimento e validação de um método analítico por espectrofotometria UV para quantificação de carvedilol Development and validation of a UV spectrophotometric method to quantify carvedilol
<abstract language="eng">This paper reports the development and validation of a new analytical method using UV spectrophotometry to quantify carvedilol (CRV) in hydrophilic matrices and raw material. This method was shown to be linear, accurate, precise, robust and to have adequate l...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2013-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000400017 |
| _version_ | 1829462512809017344 |
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| author | Paola Aline Amarante Borba Manoela Klüppel Riekes Rafael Nicolay Pereira Hellen Karine Stulzer Debora Dalla Vecchia |
| author_facet | Paola Aline Amarante Borba Manoela Klüppel Riekes Rafael Nicolay Pereira Hellen Karine Stulzer Debora Dalla Vecchia |
| author_sort | Paola Aline Amarante Borba |
| collection | DOAJ |
| description | <abstract language="eng">This paper reports the development and validation of a new analytical method using UV spectrophotometry to quantify carvedilol (CRV) in hydrophilic matrices and raw material. This method was shown to be linear, accurate, precise, robust and to have adequate limits of quantification and detection (LQ and LD, respectively), allowing its use in the dissolution test of hydrophilic matrices. The content of CRV determined through this method was compared with two previously validated methods based on the reference techniques of High Performance Liquid Chromatography (HPLC) and Potentiometric Titrations (PT). ANOVA confirmed the equivalence of these methods, showing no significant differences. |
| first_indexed | 2024-12-12T12:11:16Z |
| format | Article |
| id | doaj.art-f9ed0a37370342c597a94e9ae2b71415 |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-12-12T12:11:16Z |
| publishDate | 2013-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-f9ed0a37370342c597a94e9ae2b714152022-12-22T00:24:52ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642013-01-01364582586Desenvolvimento e validação de um método analítico por espectrofotometria UV para quantificação de carvedilol Development and validation of a UV spectrophotometric method to quantify carvedilolPaola Aline Amarante BorbaManoela Klüppel RiekesRafael Nicolay PereiraHellen Karine StulzerDebora Dalla Vecchia<abstract language="eng">This paper reports the development and validation of a new analytical method using UV spectrophotometry to quantify carvedilol (CRV) in hydrophilic matrices and raw material. This method was shown to be linear, accurate, precise, robust and to have adequate limits of quantification and detection (LQ and LD, respectively), allowing its use in the dissolution test of hydrophilic matrices. The content of CRV determined through this method was compared with two previously validated methods based on the reference techniques of High Performance Liquid Chromatography (HPLC) and Potentiometric Titrations (PT). ANOVA confirmed the equivalence of these methods, showing no significant differences.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000400017carvedilolUV spectrophotometryvalidation |
| spellingShingle | Paola Aline Amarante Borba Manoela Klüppel Riekes Rafael Nicolay Pereira Hellen Karine Stulzer Debora Dalla Vecchia Desenvolvimento e validação de um método analítico por espectrofotometria UV para quantificação de carvedilol Development and validation of a UV spectrophotometric method to quantify carvedilol Química Nova carvedilol UV spectrophotometry validation |
| title | Desenvolvimento e validação de um método analítico por espectrofotometria UV para quantificação de carvedilol Development and validation of a UV spectrophotometric method to quantify carvedilol |
| title_full | Desenvolvimento e validação de um método analítico por espectrofotometria UV para quantificação de carvedilol Development and validation of a UV spectrophotometric method to quantify carvedilol |
| title_fullStr | Desenvolvimento e validação de um método analítico por espectrofotometria UV para quantificação de carvedilol Development and validation of a UV spectrophotometric method to quantify carvedilol |
| title_full_unstemmed | Desenvolvimento e validação de um método analítico por espectrofotometria UV para quantificação de carvedilol Development and validation of a UV spectrophotometric method to quantify carvedilol |
| title_short | Desenvolvimento e validação de um método analítico por espectrofotometria UV para quantificação de carvedilol Development and validation of a UV spectrophotometric method to quantify carvedilol |
| title_sort | desenvolvimento e validacao de um metodo analitico por espectrofotometria uv para quantificacao de carvedilol development and validation of a uv spectrophotometric method to quantify carvedilol |
| topic | carvedilol UV spectrophotometry validation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000400017 |
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