Multifunctional Nature of the Arenavirus RING Finger Protein Z
Arenaviruses are a family of enveloped negative-stranded RNA viruses that can cause severe human disease ranging from encephalitis symptoms to fulminant hemorrhagic fever. The bi‑segmented RNA genome encodes four polypeptides: the nucleoprotein NP, the surface glycoprotein GP, the polymerase L, and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-11-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/4/11/2973 |
| _version_ | 1811325206957916160 |
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| author | Thomas Strecker Frank Lennartz Sarah Katharina Fehling |
| author_facet | Thomas Strecker Frank Lennartz Sarah Katharina Fehling |
| author_sort | Thomas Strecker |
| collection | DOAJ |
| description | Arenaviruses are a family of enveloped negative-stranded RNA viruses that can cause severe human disease ranging from encephalitis symptoms to fulminant hemorrhagic fever. The bi‑segmented RNA genome encodes four polypeptides: the nucleoprotein NP, the surface glycoprotein GP, the polymerase L, and the RING finger protein Z. Although it is the smallest arenavirus protein with a length of 90 to 99 amino acids and a molecular weight of approx. 11 kDa, the Z protein has multiple functions in the viral life cycle including (i) regulation of viral RNA synthesis, (ii) orchestration of viral assembly and budding, (iii) interaction with host cell proteins, and (iv) interferon antagonism. In this review, we summarize our current understanding of the structural and functional role of the Z protein in the arenavirus replication cycle. |
| first_indexed | 2024-04-13T14:29:03Z |
| format | Article |
| id | doaj.art-f9ed7efc358b4adb97338f04b6b355d3 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-13T14:29:03Z |
| publishDate | 2012-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-f9ed7efc358b4adb97338f04b6b355d32022-12-22T02:43:14ZengMDPI AGViruses1999-49152012-11-014112973301110.3390/v4112973Multifunctional Nature of the Arenavirus RING Finger Protein ZThomas StreckerFrank LennartzSarah Katharina FehlingArenaviruses are a family of enveloped negative-stranded RNA viruses that can cause severe human disease ranging from encephalitis symptoms to fulminant hemorrhagic fever. The bi‑segmented RNA genome encodes four polypeptides: the nucleoprotein NP, the surface glycoprotein GP, the polymerase L, and the RING finger protein Z. Although it is the smallest arenavirus protein with a length of 90 to 99 amino acids and a molecular weight of approx. 11 kDa, the Z protein has multiple functions in the viral life cycle including (i) regulation of viral RNA synthesis, (ii) orchestration of viral assembly and budding, (iii) interaction with host cell proteins, and (iv) interferon antagonism. In this review, we summarize our current understanding of the structural and functional role of the Z protein in the arenavirus replication cycle.http://www.mdpi.com/1999-4915/4/11/2973ArenavirusESCRTLassa virusLymphocytic choriomeningitis virusJunin virusmatrix proteinRING finger proteinvirus assembly and buddingvirus-host cell interactionZ protein |
| spellingShingle | Thomas Strecker Frank Lennartz Sarah Katharina Fehling Multifunctional Nature of the Arenavirus RING Finger Protein Z Viruses Arenavirus ESCRT Lassa virus Lymphocytic choriomeningitis virus Junin virus matrix protein RING finger protein virus assembly and budding virus-host cell interaction Z protein |
| title | Multifunctional Nature of the Arenavirus RING Finger Protein Z |
| title_full | Multifunctional Nature of the Arenavirus RING Finger Protein Z |
| title_fullStr | Multifunctional Nature of the Arenavirus RING Finger Protein Z |
| title_full_unstemmed | Multifunctional Nature of the Arenavirus RING Finger Protein Z |
| title_short | Multifunctional Nature of the Arenavirus RING Finger Protein Z |
| title_sort | multifunctional nature of the arenavirus ring finger protein z |
| topic | Arenavirus ESCRT Lassa virus Lymphocytic choriomeningitis virus Junin virus matrix protein RING finger protein virus assembly and budding virus-host cell interaction Z protein |
| url | http://www.mdpi.com/1999-4915/4/11/2973 |
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