Contribution of Macrophages and T Cells in Skeletal Metastasis
Bone is a common site for metastases with a local microenvironment that is highly conducive for tumor establishment and growth. The bone marrow is replete with myeloid and lymphoid linage cells that provide a fertile niche for metastatic cancer cells promoting their survival and growth. Here, we dis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/4/1014 |
| _version_ | 1797570149092425728 |
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| author | Veronica Mendoza-Reinoso Laurie K. McCauley Pierrick G.J. Fournier |
| author_facet | Veronica Mendoza-Reinoso Laurie K. McCauley Pierrick G.J. Fournier |
| author_sort | Veronica Mendoza-Reinoso |
| collection | DOAJ |
| description | Bone is a common site for metastases with a local microenvironment that is highly conducive for tumor establishment and growth. The bone marrow is replete with myeloid and lymphoid linage cells that provide a fertile niche for metastatic cancer cells promoting their survival and growth. Here, we discuss the role of macrophages and T cells in pro- and anti-tumoral mechanisms, their interaction to support cancer cell growth, and their contribution to the development of skeletal metastases. Importantly, immunotherapeutic strategies targeting macrophages and T cells in cancer are also discussed in this review as they represent a great promise for patients suffering from incurable bone metastases. |
| first_indexed | 2024-03-10T20:20:50Z |
| format | Article |
| id | doaj.art-f9eded782dcb490c921838469513f1ec |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T20:20:50Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f9eded782dcb490c921838469513f1ec2023-11-19T22:12:31ZengMDPI AGCancers2072-66942020-04-01124101410.3390/cancers12041014Contribution of Macrophages and T Cells in Skeletal MetastasisVeronica Mendoza-Reinoso0Laurie K. McCauley1Pierrick G.J. Fournier2Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USADepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USABiomedical Innovation Department, Centro de Investigación Científica y de Educación Superior de Ensenada, Ensenada, BC 22860, MexicoBone is a common site for metastases with a local microenvironment that is highly conducive for tumor establishment and growth. The bone marrow is replete with myeloid and lymphoid linage cells that provide a fertile niche for metastatic cancer cells promoting their survival and growth. Here, we discuss the role of macrophages and T cells in pro- and anti-tumoral mechanisms, their interaction to support cancer cell growth, and their contribution to the development of skeletal metastases. Importantly, immunotherapeutic strategies targeting macrophages and T cells in cancer are also discussed in this review as they represent a great promise for patients suffering from incurable bone metastases.https://www.mdpi.com/2072-6694/12/4/1014bone metastasisTAMsMAMsmacrophage polarizationefferocytosisT cells |
| spellingShingle | Veronica Mendoza-Reinoso Laurie K. McCauley Pierrick G.J. Fournier Contribution of Macrophages and T Cells in Skeletal Metastasis Cancers bone metastasis TAMs MAMs macrophage polarization efferocytosis T cells |
| title | Contribution of Macrophages and T Cells in Skeletal Metastasis |
| title_full | Contribution of Macrophages and T Cells in Skeletal Metastasis |
| title_fullStr | Contribution of Macrophages and T Cells in Skeletal Metastasis |
| title_full_unstemmed | Contribution of Macrophages and T Cells in Skeletal Metastasis |
| title_short | Contribution of Macrophages and T Cells in Skeletal Metastasis |
| title_sort | contribution of macrophages and t cells in skeletal metastasis |
| topic | bone metastasis TAMs MAMs macrophage polarization efferocytosis T cells |
| url | https://www.mdpi.com/2072-6694/12/4/1014 |
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