A-Type Natriuretic Peptide Alters the Impact of Azithromycin on Planktonic Culture and on (Monospecies and Binary) Biofilms of Skin Bacteria <i>Kytococcus schroeteri</i> and <i>Staphylococcus aureus</i>
It has been established that the human atrial natriuretic peptide is able to alter the effect of azithromycin on <i>Kytococcus schroeteri</i> H01 and <i>Staphylococcus aureus</i> 209P monospecies and binary biofilms. The effect of the hormone depends on the surface type and c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/11/12/2965 |
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| author | Ekaterina V. Diuvenji Ekaterina D. Nevolina Ilya D. Solovyev Marina V. Sukhacheva Sergey V. Mart’yanov Aleksandra S. Novikova Marina V. Zhurina Vladimir K. Plakunov Andrei V. Gannesen |
| author_facet | Ekaterina V. Diuvenji Ekaterina D. Nevolina Ilya D. Solovyev Marina V. Sukhacheva Sergey V. Mart’yanov Aleksandra S. Novikova Marina V. Zhurina Vladimir K. Plakunov Andrei V. Gannesen |
| author_sort | Ekaterina V. Diuvenji |
| collection | DOAJ |
| description | It has been established that the human atrial natriuretic peptide is able to alter the effect of azithromycin on <i>Kytococcus schroeteri</i> H01 and <i>Staphylococcus aureus</i> 209P monospecies and binary biofilms. The effect of the hormone depends on the surface type and cultivation system, and it may have both enhancing and counteracting effects. The antagonistic effect of the hormone was observed mostly on hydrophobic surfaces, whereas the additive effect was observed on hydrophilic surfaces like glass. Also, the effect of the hormone depends on the antibiotic concentration and bacterial species. The combination of azithromycin and ANP led to an amplification of cell aggregation in biofilms, to the potential increase in matrix synthesis, and to a decrease in <i>S. aureus</i> in the binary community. Also, ANP, azithromycin, and their combinations caused the differential expression of genes of resistance to different antibiotics, like macrolides (mostly increasing expression in kytococci), fluoroquinolones, aminoglycosides, and others, in both bacteria. |
| first_indexed | 2024-03-08T20:31:29Z |
| format | Article |
| id | doaj.art-f9f16f367d2a4db4abe62ec431e9a981 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-08T20:31:29Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-f9f16f367d2a4db4abe62ec431e9a9812023-12-22T14:26:14ZengMDPI AGMicroorganisms2076-26072023-12-011112296510.3390/microorganisms11122965A-Type Natriuretic Peptide Alters the Impact of Azithromycin on Planktonic Culture and on (Monospecies and Binary) Biofilms of Skin Bacteria <i>Kytococcus schroeteri</i> and <i>Staphylococcus aureus</i>Ekaterina V. Diuvenji0Ekaterina D. Nevolina1Ilya D. Solovyev2Marina V. Sukhacheva3Sergey V. Mart’yanov4Aleksandra S. Novikova5Marina V. Zhurina6Vladimir K. Plakunov7Andrei V. Gannesen8Federal Research Center “Fundamentals of Biotechnology”, Russian Academy of Sciences, 119071 Moscow, RussiaFederal Research Center “Fundamentals of Biotechnology”, Russian Academy of Sciences, 119071 Moscow, RussiaFederal Research Center “Fundamentals of Biotechnology”, Russian Academy of Sciences, 119071 Moscow, RussiaFederal Research Center “Fundamentals of Biotechnology”, Russian Academy of Sciences, 119071 Moscow, RussiaFederal Research Center “Fundamentals of Biotechnology”, Russian Academy of Sciences, 119071 Moscow, RussiaLLC “BAVAR+”, 129626 Moscow, RussiaFederal Research Center “Fundamentals of Biotechnology”, Russian Academy of Sciences, 119071 Moscow, RussiaFederal Research Center “Fundamentals of Biotechnology”, Russian Academy of Sciences, 119071 Moscow, RussiaFederal Research Center “Fundamentals of Biotechnology”, Russian Academy of Sciences, 119071 Moscow, RussiaIt has been established that the human atrial natriuretic peptide is able to alter the effect of azithromycin on <i>Kytococcus schroeteri</i> H01 and <i>Staphylococcus aureus</i> 209P monospecies and binary biofilms. The effect of the hormone depends on the surface type and cultivation system, and it may have both enhancing and counteracting effects. The antagonistic effect of the hormone was observed mostly on hydrophobic surfaces, whereas the additive effect was observed on hydrophilic surfaces like glass. Also, the effect of the hormone depends on the antibiotic concentration and bacterial species. The combination of azithromycin and ANP led to an amplification of cell aggregation in biofilms, to the potential increase in matrix synthesis, and to a decrease in <i>S. aureus</i> in the binary community. Also, ANP, azithromycin, and their combinations caused the differential expression of genes of resistance to different antibiotics, like macrolides (mostly increasing expression in kytococci), fluoroquinolones, aminoglycosides, and others, in both bacteria.https://www.mdpi.com/2076-2607/11/12/2965<i>Staphylococcus aureus</i><i>Kytococcus schroeteri</i>atrial natriuretic peptidesbiofilmsmultispecies biofilmshuman skin microbiota |
| spellingShingle | Ekaterina V. Diuvenji Ekaterina D. Nevolina Ilya D. Solovyev Marina V. Sukhacheva Sergey V. Mart’yanov Aleksandra S. Novikova Marina V. Zhurina Vladimir K. Plakunov Andrei V. Gannesen A-Type Natriuretic Peptide Alters the Impact of Azithromycin on Planktonic Culture and on (Monospecies and Binary) Biofilms of Skin Bacteria <i>Kytococcus schroeteri</i> and <i>Staphylococcus aureus</i> Microorganisms <i>Staphylococcus aureus</i> <i>Kytococcus schroeteri</i> atrial natriuretic peptides biofilms multispecies biofilms human skin microbiota |
| title | A-Type Natriuretic Peptide Alters the Impact of Azithromycin on Planktonic Culture and on (Monospecies and Binary) Biofilms of Skin Bacteria <i>Kytococcus schroeteri</i> and <i>Staphylococcus aureus</i> |
| title_full | A-Type Natriuretic Peptide Alters the Impact of Azithromycin on Planktonic Culture and on (Monospecies and Binary) Biofilms of Skin Bacteria <i>Kytococcus schroeteri</i> and <i>Staphylococcus aureus</i> |
| title_fullStr | A-Type Natriuretic Peptide Alters the Impact of Azithromycin on Planktonic Culture and on (Monospecies and Binary) Biofilms of Skin Bacteria <i>Kytococcus schroeteri</i> and <i>Staphylococcus aureus</i> |
| title_full_unstemmed | A-Type Natriuretic Peptide Alters the Impact of Azithromycin on Planktonic Culture and on (Monospecies and Binary) Biofilms of Skin Bacteria <i>Kytococcus schroeteri</i> and <i>Staphylococcus aureus</i> |
| title_short | A-Type Natriuretic Peptide Alters the Impact of Azithromycin on Planktonic Culture and on (Monospecies and Binary) Biofilms of Skin Bacteria <i>Kytococcus schroeteri</i> and <i>Staphylococcus aureus</i> |
| title_sort | a type natriuretic peptide alters the impact of azithromycin on planktonic culture and on monospecies and binary biofilms of skin bacteria i kytococcus schroeteri i and i staphylococcus aureus i |
| topic | <i>Staphylococcus aureus</i> <i>Kytococcus schroeteri</i> atrial natriuretic peptides biofilms multispecies biofilms human skin microbiota |
| url | https://www.mdpi.com/2076-2607/11/12/2965 |
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