A Systematic Review on the Effectiveness of Antipsychotic Drugs on the Quality of Life of Patients with Schizophrenia
Pharmacological antipsychotic drug interventions represent the cornerstone of the management of patients with schizophrenia and other psychotic spectrum disorders. The choice of the “best” treatment should be made on the basis of several clinical domains. However, despite available treatments, the q...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/11/1577 |
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| author | Gaia Sampogna Matteo Di Vincenzo Luigi Giuliani Giulia Menculini Emiliana Mancuso Eleonora Arsenio Salvatore Cipolla Bianca Della Rocca Vassilis Martiadis Maria Salvina Signorelli Andrea Fiorillo |
| author_facet | Gaia Sampogna Matteo Di Vincenzo Luigi Giuliani Giulia Menculini Emiliana Mancuso Eleonora Arsenio Salvatore Cipolla Bianca Della Rocca Vassilis Martiadis Maria Salvina Signorelli Andrea Fiorillo |
| author_sort | Gaia Sampogna |
| collection | DOAJ |
| description | Pharmacological antipsychotic drug interventions represent the cornerstone of the management of patients with schizophrenia and other psychotic spectrum disorders. The choice of the “best” treatment should be made on the basis of several clinical domains. However, despite available treatments, the quality of life reported by patients with schizophrenia taking antipsychotics is still very poor, and this outcome is rarely taken into account in trials assessing the efficacy and effectiveness of antipsychotic treatments. Therefore, we performed a systematic review in order to assess the impact of antipsychotic treatment on patients’ quality of life. In particular, we aimed to identify any differences in the improvement in quality of life according to the (a) type of formulation of antipsychotic drugs (i.e., oral vs. depot vs. long-acting injectable); (b) type of the drug (first vs. second vs. third generation); and (c) patients’ clinical characteristics. One hundred and eleven papers were included in the review. The main findings were as follows: (1) quality of life is usually considered a secondary outcome in trials on the efficacy and effectiveness of drugs; (2) second-generation antipsychotics have a more positive effect on quality of life; and (3) long-acting injectable antipsychotics are associated with a more stable improvement in quality of life and with a good safety and tolerability profile. Our systematic review confirms that quality of life represents a central element for selecting the appropriate treatment for people with schizophrenia. In particular, the availability of new treatments with a better tolerability profile, a proven effectiveness on patients’ cognitive and social functioning, and with a more stable blood concentration might represent the appropriate strategy for improving the quality of life of people with schizophrenia. |
| first_indexed | 2024-03-09T16:59:10Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T16:59:10Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-f9f1e6627e71446b85557b8a43018cd12023-11-24T14:32:48ZengMDPI AGBrain Sciences2076-34252023-11-011311157710.3390/brainsci13111577A Systematic Review on the Effectiveness of Antipsychotic Drugs on the Quality of Life of Patients with SchizophreniaGaia Sampogna0Matteo Di Vincenzo1Luigi Giuliani2Giulia Menculini3Emiliana Mancuso4Eleonora Arsenio5Salvatore Cipolla6Bianca Della Rocca7Vassilis Martiadis8Maria Salvina Signorelli9Andrea Fiorillo10Department of Psychiatry, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Psychiatry, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Psychiatry, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Psychiatry, University of Perugia, 06132 Perugia, ItalyDepartment of Psychiatry, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Psychiatry, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Psychiatry, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Psychiatry, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Mental Health, ASL Napoli 1 Centro, 80147 Naples, ItalyDepartment of Psychiatry, University of Catania, 95124 Catania, ItalyDepartment of Psychiatry, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyPharmacological antipsychotic drug interventions represent the cornerstone of the management of patients with schizophrenia and other psychotic spectrum disorders. The choice of the “best” treatment should be made on the basis of several clinical domains. However, despite available treatments, the quality of life reported by patients with schizophrenia taking antipsychotics is still very poor, and this outcome is rarely taken into account in trials assessing the efficacy and effectiveness of antipsychotic treatments. Therefore, we performed a systematic review in order to assess the impact of antipsychotic treatment on patients’ quality of life. In particular, we aimed to identify any differences in the improvement in quality of life according to the (a) type of formulation of antipsychotic drugs (i.e., oral vs. depot vs. long-acting injectable); (b) type of the drug (first vs. second vs. third generation); and (c) patients’ clinical characteristics. One hundred and eleven papers were included in the review. The main findings were as follows: (1) quality of life is usually considered a secondary outcome in trials on the efficacy and effectiveness of drugs; (2) second-generation antipsychotics have a more positive effect on quality of life; and (3) long-acting injectable antipsychotics are associated with a more stable improvement in quality of life and with a good safety and tolerability profile. Our systematic review confirms that quality of life represents a central element for selecting the appropriate treatment for people with schizophrenia. In particular, the availability of new treatments with a better tolerability profile, a proven effectiveness on patients’ cognitive and social functioning, and with a more stable blood concentration might represent the appropriate strategy for improving the quality of life of people with schizophrenia.https://www.mdpi.com/2076-3425/13/11/1577schizophreniaquality of lifeantipsychotic drugspersonalized treatmentneurolepticsoutcome assessment |
| spellingShingle | Gaia Sampogna Matteo Di Vincenzo Luigi Giuliani Giulia Menculini Emiliana Mancuso Eleonora Arsenio Salvatore Cipolla Bianca Della Rocca Vassilis Martiadis Maria Salvina Signorelli Andrea Fiorillo A Systematic Review on the Effectiveness of Antipsychotic Drugs on the Quality of Life of Patients with Schizophrenia Brain Sciences schizophrenia quality of life antipsychotic drugs personalized treatment neuroleptics outcome assessment |
| title | A Systematic Review on the Effectiveness of Antipsychotic Drugs on the Quality of Life of Patients with Schizophrenia |
| title_full | A Systematic Review on the Effectiveness of Antipsychotic Drugs on the Quality of Life of Patients with Schizophrenia |
| title_fullStr | A Systematic Review on the Effectiveness of Antipsychotic Drugs on the Quality of Life of Patients with Schizophrenia |
| title_full_unstemmed | A Systematic Review on the Effectiveness of Antipsychotic Drugs on the Quality of Life of Patients with Schizophrenia |
| title_short | A Systematic Review on the Effectiveness of Antipsychotic Drugs on the Quality of Life of Patients with Schizophrenia |
| title_sort | systematic review on the effectiveness of antipsychotic drugs on the quality of life of patients with schizophrenia |
| topic | schizophrenia quality of life antipsychotic drugs personalized treatment neuroleptics outcome assessment |
| url | https://www.mdpi.com/2076-3425/13/11/1577 |
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