Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases
Kleiner and co-workers profile RNA 5-methylcytidine (m5C) dioxygenase enzymes using an activity-based metabolic probing strategy. They reveal ALKBH1 as the major 5-formylcytidine (f5C) writer and characterize modification sites across mRNA and tRNA.
Main Authors: | A. Emilia Arguello, Ang Li, Xuemeng Sun, Tanner W. Eggert, Elisabeth Mairhofer, Ralph E. Kleiner |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-07-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-31876-2 |
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