External Validation of the ImAgeS Risk Score for Mortality in Hospitalized Kidney Transplant Recipients with COVID-19: A Retrospective Observational Study
Background: Timely recognition of high-risk individuals with novel Coronavirus disease (COVID-19) is important. Yet, validated risk scores for kidney transplant recipients with COVID-19 are lacking. The present study aimed to externally validate the novel ImAgeS risk score in this population. Method...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | BioMed |
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| Online Access: | https://www.mdpi.com/2673-8430/3/2/18 |
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| author | Josipa Domjanović Tea Domjanović Škopinić Tea Gamberažić Kirevski Andrija Matetic |
| author_facet | Josipa Domjanović Tea Domjanović Škopinić Tea Gamberažić Kirevski Andrija Matetic |
| author_sort | Josipa Domjanović |
| collection | DOAJ |
| description | Background: Timely recognition of high-risk individuals with novel Coronavirus disease (COVID-19) is important. Yet, validated risk scores for kidney transplant recipients with COVID-19 are lacking. The present study aimed to externally validate the novel ImAgeS risk score in this population. Methods: A retrospective analysis of 65 kidney transplant recipients with COVID-19 was conducted. A robust external validation of the novel ImAgeS risk score with respect to 30-day all-cause mortality was performed using regression analysis, discrimination and calibration methods. Results: An overall mortality rate during the study follow-up was 18.5% (N = 12). The ImAgeS risk score showed a statistically significant association with 30-day all-cause mortality (HR 1.04 95% CI 1.00–1.08, <i>p</i> = 0.040). This risk score demonstrated a modest, statistically significant discrimination of all-cause mortality (AUC of 0.679 (95% CI 0.519–0.840, <i>p</i> = 0.027). The calibration of the model was acceptable with a Hosmer-Lemeshow value of 3.74, Harrell’s C concordance index of 0.699 and Somers’ D of 0.397. Conclusions: The ImAgeS risk score demonstrated a significant association with 30-day all-cause mortality in kidney transplant recipients with COVID-19. The model showed modest discrimination and satisfactory calibration, confirming the findings from the computational study. Further studies are needed to determine the utility of the ImAgeS score in this high-risk population. |
| first_indexed | 2024-03-11T02:45:19Z |
| format | Article |
| id | doaj.art-f9f337897cb0414cb8b15dea96140385 |
| institution | Directory Open Access Journal |
| issn | 2673-8430 |
| language | English |
| last_indexed | 2024-03-11T02:45:19Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | BioMed |
| spelling | doaj.art-f9f337897cb0414cb8b15dea961403852023-11-18T09:24:10ZengMDPI AGBioMed2673-84302023-04-013220721610.3390/biomed3020018External Validation of the ImAgeS Risk Score for Mortality in Hospitalized Kidney Transplant Recipients with COVID-19: A Retrospective Observational StudyJosipa Domjanović0Tea Domjanović Škopinić1Tea Gamberažić Kirevski2Andrija Matetic3Department of Nephrology, University Hospital of Split, 21000 Split, CroatiaDepartment of Cardiology, University Hospital of Split, 21000 Split, CroatiaDepartment of Anesthesiology, University Hospital of Split, 21000 Split, CroatiaDepartment of Cardiology, University Hospital of Split, 21000 Split, CroatiaBackground: Timely recognition of high-risk individuals with novel Coronavirus disease (COVID-19) is important. Yet, validated risk scores for kidney transplant recipients with COVID-19 are lacking. The present study aimed to externally validate the novel ImAgeS risk score in this population. Methods: A retrospective analysis of 65 kidney transplant recipients with COVID-19 was conducted. A robust external validation of the novel ImAgeS risk score with respect to 30-day all-cause mortality was performed using regression analysis, discrimination and calibration methods. Results: An overall mortality rate during the study follow-up was 18.5% (N = 12). The ImAgeS risk score showed a statistically significant association with 30-day all-cause mortality (HR 1.04 95% CI 1.00–1.08, <i>p</i> = 0.040). This risk score demonstrated a modest, statistically significant discrimination of all-cause mortality (AUC of 0.679 (95% CI 0.519–0.840, <i>p</i> = 0.027). The calibration of the model was acceptable with a Hosmer-Lemeshow value of 3.74, Harrell’s C concordance index of 0.699 and Somers’ D of 0.397. Conclusions: The ImAgeS risk score demonstrated a significant association with 30-day all-cause mortality in kidney transplant recipients with COVID-19. The model showed modest discrimination and satisfactory calibration, confirming the findings from the computational study. Further studies are needed to determine the utility of the ImAgeS score in this high-risk population.https://www.mdpi.com/2673-8430/3/2/18ImAgeS scorekidney transplant recipientsCOVID-19mortality |
| spellingShingle | Josipa Domjanović Tea Domjanović Škopinić Tea Gamberažić Kirevski Andrija Matetic External Validation of the ImAgeS Risk Score for Mortality in Hospitalized Kidney Transplant Recipients with COVID-19: A Retrospective Observational Study BioMed ImAgeS score kidney transplant recipients COVID-19 mortality |
| title | External Validation of the ImAgeS Risk Score for Mortality in Hospitalized Kidney Transplant Recipients with COVID-19: A Retrospective Observational Study |
| title_full | External Validation of the ImAgeS Risk Score for Mortality in Hospitalized Kidney Transplant Recipients with COVID-19: A Retrospective Observational Study |
| title_fullStr | External Validation of the ImAgeS Risk Score for Mortality in Hospitalized Kidney Transplant Recipients with COVID-19: A Retrospective Observational Study |
| title_full_unstemmed | External Validation of the ImAgeS Risk Score for Mortality in Hospitalized Kidney Transplant Recipients with COVID-19: A Retrospective Observational Study |
| title_short | External Validation of the ImAgeS Risk Score for Mortality in Hospitalized Kidney Transplant Recipients with COVID-19: A Retrospective Observational Study |
| title_sort | external validation of the images risk score for mortality in hospitalized kidney transplant recipients with covid 19 a retrospective observational study |
| topic | ImAgeS score kidney transplant recipients COVID-19 mortality |
| url | https://www.mdpi.com/2673-8430/3/2/18 |
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