Phytochemical Profile and Anticancer Potential of Endophytic Microorganisms from Liverwort Species, <i>Marchantia polymorpha</i> L.
Liverwort endophytes could be a source of new biologically active substances, especially when these spore-forming plants are known to produce compounds that are not found in other living organisms. Despite the significant development of plant endophytes research, there are only a few studies describ...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/1/153 |
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| author | Mateusz Stelmasiewicz Łukasz Świątek Agnieszka Ludwiczuk |
| author_facet | Mateusz Stelmasiewicz Łukasz Świątek Agnieszka Ludwiczuk |
| author_sort | Mateusz Stelmasiewicz |
| collection | DOAJ |
| description | Liverwort endophytes could be a source of new biologically active substances, especially when these spore-forming plants are known to produce compounds that are not found in other living organisms. Despite the significant development of plant endophytes research, there are only a few studies describing liverwort endophytic microorganisms and their metabolites. In the presented study, the analysis of the volatile compounds obtained from thallose liverwort species, <i>Marchantia polymorpha</i> L., and its endophytes was carried out. For this purpose, non-polar extracts of plant material and symbiotic microorganisms were obtained. The extracts were analyzed using gas chromatography coupled to mass spectrometry. Compounds with the structure of diketopiperazine in the endophyte extract were identified. Liverwort volatile extract was a rich source of cuparane-, chamigrane-, acorane-, and thujopsane-type sesquiterpenoids. The cytotoxicity of ethyl acetate extracts from endophytic microorganisms was evaluated on a panel of cancer (FaDu, HeLa, and SCC-25) cell lines and normal (VERO), and revealed significant anticancer potential towards hypopharyngeal squamous cell carcinoma and cervical adenocarcinoma. |
| first_indexed | 2024-03-10T03:31:24Z |
| format | Article |
| id | doaj.art-f9f377888b1341aaa384260a857ba646 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:31:24Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f9f377888b1341aaa384260a857ba6462023-11-23T11:57:29ZengMDPI AGMolecules1420-30492021-12-0127115310.3390/molecules27010153Phytochemical Profile and Anticancer Potential of Endophytic Microorganisms from Liverwort Species, <i>Marchantia polymorpha</i> L.Mateusz Stelmasiewicz0Łukasz Świątek1Agnieszka Ludwiczuk2Department of Pharmacognosy with the Medicinal Plant Garden, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Virology with SARS Laboratory, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Pharmacognosy with the Medicinal Plant Garden, Medical University of Lublin, 20-093 Lublin, PolandLiverwort endophytes could be a source of new biologically active substances, especially when these spore-forming plants are known to produce compounds that are not found in other living organisms. Despite the significant development of plant endophytes research, there are only a few studies describing liverwort endophytic microorganisms and their metabolites. In the presented study, the analysis of the volatile compounds obtained from thallose liverwort species, <i>Marchantia polymorpha</i> L., and its endophytes was carried out. For this purpose, non-polar extracts of plant material and symbiotic microorganisms were obtained. The extracts were analyzed using gas chromatography coupled to mass spectrometry. Compounds with the structure of diketopiperazine in the endophyte extract were identified. Liverwort volatile extract was a rich source of cuparane-, chamigrane-, acorane-, and thujopsane-type sesquiterpenoids. The cytotoxicity of ethyl acetate extracts from endophytic microorganisms was evaluated on a panel of cancer (FaDu, HeLa, and SCC-25) cell lines and normal (VERO), and revealed significant anticancer potential towards hypopharyngeal squamous cell carcinoma and cervical adenocarcinoma.https://www.mdpi.com/1420-3049/27/1/153liverworts<i>Marchantia polymorpha</i>endophytesdiketopiperazinesesquiterpenoidsanticancer activity |
| spellingShingle | Mateusz Stelmasiewicz Łukasz Świątek Agnieszka Ludwiczuk Phytochemical Profile and Anticancer Potential of Endophytic Microorganisms from Liverwort Species, <i>Marchantia polymorpha</i> L. Molecules liverworts <i>Marchantia polymorpha</i> endophytes diketopiperazine sesquiterpenoids anticancer activity |
| title | Phytochemical Profile and Anticancer Potential of Endophytic Microorganisms from Liverwort Species, <i>Marchantia polymorpha</i> L. |
| title_full | Phytochemical Profile and Anticancer Potential of Endophytic Microorganisms from Liverwort Species, <i>Marchantia polymorpha</i> L. |
| title_fullStr | Phytochemical Profile and Anticancer Potential of Endophytic Microorganisms from Liverwort Species, <i>Marchantia polymorpha</i> L. |
| title_full_unstemmed | Phytochemical Profile and Anticancer Potential of Endophytic Microorganisms from Liverwort Species, <i>Marchantia polymorpha</i> L. |
| title_short | Phytochemical Profile and Anticancer Potential of Endophytic Microorganisms from Liverwort Species, <i>Marchantia polymorpha</i> L. |
| title_sort | phytochemical profile and anticancer potential of endophytic microorganisms from liverwort species i marchantia polymorpha i l |
| topic | liverworts <i>Marchantia polymorpha</i> endophytes diketopiperazine sesquiterpenoids anticancer activity |
| url | https://www.mdpi.com/1420-3049/27/1/153 |
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