Protective effect of baclofen on ovarian cystogenesis and morphine-induced lipid profile change in female rats
Introduction: Morphine induces ovarian cysts that cause obesity and disrupt sex hormone secretion. Baclofen, a gamma-aminobutyric acid receptor agonist, can help regulate sex hormones and reduce harmful blood lipids by protecting against morphine-induced gamma-aminobutyric acid inhibition. We invest...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2024;volume=28;issue=1;spage=43;epage=46;aulast=Jamshidi |
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| author | Zahra Jamshidi Manizheh Karami Mohsen Khalili Mehrdad Roghani |
| author_facet | Zahra Jamshidi Manizheh Karami Mohsen Khalili Mehrdad Roghani |
| author_sort | Zahra Jamshidi |
| collection | DOAJ |
| description | Introduction: Morphine induces ovarian cysts that cause obesity and disrupt sex hormone secretion. Baclofen, a gamma-aminobutyric acid receptor agonist, can help regulate sex hormones and reduce harmful blood lipids by protecting against morphine-induced gamma-aminobutyric acid inhibition. We investigated the prophylactic effect of baclofen in rats receiving morphine by comparing with the untreated groups. Materials and Methods: Forty eight female Wistar rats were randomly divided into several groups, including control (saline 1 mL/kg, i.p.), morphine (5 mg/kg, i.p.), baclofen (10, 20, and 30 mg/kg, i.p.), and baclofen (10, 20, and 30 mg/kg) before morphine (5 mg/kg). Twenty four hours after the treatment, blood and serum samples were taken to check the levels of gonadotropins (LH & FSH) and lipid profile. The ovaries and uterus were also studied, and a proinflammatory nitric oxide (NO) diagnostic test was completed. The results were analyzed using analysis of variance (α = 0.05). Results: In comparison with the control group, the levels of LH and not FSH decreased in the morphine group and the number of ovarian cysts was more in the morphine group. These problems were not observed in the group of baclofen alone and baclofen + morphine. However, the triglyceride level increased slightly in the baclofen 30 mg/kg + morphine group. But the LDL level somewhat decreased. The proinflammatory NO system did not show significant activation in the ovary and uterus, except for the baclofen 10 mg/kg + baclofen group. Conclusion: Morphine can cause ovarian cysts by lowering LH but baclofen prophylaxis can protect reproductive properties by adapting major metabolic changes. |
| first_indexed | 2024-04-24T19:43:38Z |
| format | Article |
| id | doaj.art-f9f580e9746c42949d6ded8caf8d869f |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-04-24T19:43:38Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-f9f580e9746c42949d6ded8caf8d869f2024-03-25T10:27:51ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102024-01-01281434610.4103/ijem.ijem_364_22Protective effect of baclofen on ovarian cystogenesis and morphine-induced lipid profile change in female ratsZahra JamshidiManizheh KaramiMohsen KhaliliMehrdad RoghaniIntroduction: Morphine induces ovarian cysts that cause obesity and disrupt sex hormone secretion. Baclofen, a gamma-aminobutyric acid receptor agonist, can help regulate sex hormones and reduce harmful blood lipids by protecting against morphine-induced gamma-aminobutyric acid inhibition. We investigated the prophylactic effect of baclofen in rats receiving morphine by comparing with the untreated groups. Materials and Methods: Forty eight female Wistar rats were randomly divided into several groups, including control (saline 1 mL/kg, i.p.), morphine (5 mg/kg, i.p.), baclofen (10, 20, and 30 mg/kg, i.p.), and baclofen (10, 20, and 30 mg/kg) before morphine (5 mg/kg). Twenty four hours after the treatment, blood and serum samples were taken to check the levels of gonadotropins (LH & FSH) and lipid profile. The ovaries and uterus were also studied, and a proinflammatory nitric oxide (NO) diagnostic test was completed. The results were analyzed using analysis of variance (α = 0.05). Results: In comparison with the control group, the levels of LH and not FSH decreased in the morphine group and the number of ovarian cysts was more in the morphine group. These problems were not observed in the group of baclofen alone and baclofen + morphine. However, the triglyceride level increased slightly in the baclofen 30 mg/kg + morphine group. But the LDL level somewhat decreased. The proinflammatory NO system did not show significant activation in the ovary and uterus, except for the baclofen 10 mg/kg + baclofen group. Conclusion: Morphine can cause ovarian cysts by lowering LH but baclofen prophylaxis can protect reproductive properties by adapting major metabolic changes.http://www.ijem.in/article.asp?issn=2230-8210;year=2024;volume=28;issue=1;spage=43;epage=46;aulast=Jamshidibaclofencystfshmorphinelhlipidovaryno |
| spellingShingle | Zahra Jamshidi Manizheh Karami Mohsen Khalili Mehrdad Roghani Protective effect of baclofen on ovarian cystogenesis and morphine-induced lipid profile change in female rats Indian Journal of Endocrinology and Metabolism baclofen cyst fsh morphine lh lipid ovary no |
| title | Protective effect of baclofen on ovarian cystogenesis and morphine-induced lipid profile change in female rats |
| title_full | Protective effect of baclofen on ovarian cystogenesis and morphine-induced lipid profile change in female rats |
| title_fullStr | Protective effect of baclofen on ovarian cystogenesis and morphine-induced lipid profile change in female rats |
| title_full_unstemmed | Protective effect of baclofen on ovarian cystogenesis and morphine-induced lipid profile change in female rats |
| title_short | Protective effect of baclofen on ovarian cystogenesis and morphine-induced lipid profile change in female rats |
| title_sort | protective effect of baclofen on ovarian cystogenesis and morphine induced lipid profile change in female rats |
| topic | baclofen cyst fsh morphine lh lipid ovary no |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2024;volume=28;issue=1;spage=43;epage=46;aulast=Jamshidi |
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