Feto-maternal Outcome Using New Screening Criteria of Serum TSH for Diagnosing Hypothyroidism in Pregnancy
Introduction: Evidence suggests that by using the classical non pregnant reference range for serum TSH (STSH), one might miss hypothyroidism in pregnancy. Therefore, upper normal cut off value of S TSH should be taken as <2.5 mIU/L in the first trimester and <3mIU/L in the second and third...
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JCDR Research and Publications Private Limited
2015-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/5735/11106_CE[Ra1]_F(AK)_PF1(AK)_PFA(AK)_PF2(PAG).pdf |
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| author | Deeksha Joshi Rupali Dewan Rekha Bharti Karishma Thariani Aanchal Sablok Manjula Sharma Krishna Biswas Aruna Batra |
| author_facet | Deeksha Joshi Rupali Dewan Rekha Bharti Karishma Thariani Aanchal Sablok Manjula Sharma Krishna Biswas Aruna Batra |
| author_sort | Deeksha Joshi |
| collection | DOAJ |
| description | Introduction: Evidence suggests that by using the classical non
pregnant reference range for serum TSH (STSH), one might miss
hypothyroidism in pregnancy. Therefore, upper normal cut off
value of S TSH should be taken as <2.5 mIU/L in the first trimester
and <3mIU/L in the second and third trimester. However, two
Indian studies have reported higher trimester specific reference
ranges in the Indian pregnant women.
Objectives: To assess the maternal and fetal outcomes using
new screening criteria with upper S TSH cut off as >3mIU/L, for
diagnosing hypothyroidism in pregnancy.
Materials and Methods: This study was a cross sectional study,
carried out in the Department of Obstetrics and Gynaecology
of a tertiary care hospital, in collaboration with the Department
of Endocrinology. Pregnant women with ≤ 20 weeks gestation,
attending antenatal OPD from December 2010 to January 2012
were included in the study. On the basis of S TSH level, women
were divided into Study Group with S TSH level between 3.1 to
6.2 mIU/L, (new range to be studied) and an equal number of age
and parity matched Control Group with S TSH levels between
0.4 to 3 mIU/L. The maternal and fetal outcomes were compared
between study and control groups.
Results: During the study period, a total of 66 women had S TSH
between 3.1-6.2 mIU/L. Maternal and fetal outcomes in both the
groups were comparable. There was no difference in the mode of
delivery between study and control groups.
Conclusion: The lower S TSH cut off recommended for diagnosing hypothyroidism in pregnancy may not be applicable to
pregnant Indian women. |
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| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T10:21:46Z |
| publishDate | 2015-04-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-f9f5b738c5114e1b8f91eeb0481fc2202022-12-22T01:11:23ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-04-0194QC01QC0310.7860/JCDR/2015/11106.5735Feto-maternal Outcome Using New Screening Criteria of Serum TSH for Diagnosing Hypothyroidism in PregnancyDeeksha Joshi0Rupali Dewan1Rekha Bharti2Karishma Thariani3Aanchal Sablok4Manjula Sharma5Krishna Biswas6Aruna Batra7Assistant Professor, Department of Obstetrics & Gynaecology, SAIMS, Indore, India.Professor & Consultant, Department of Obstetrics & Gynaecology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.Assistant Professor, Department of Obstetrics & Gynaecology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.Reserch Officer, Human Reproductive Research Centre, ICMR & Ex senior resident, Department of Obstetrics & Gynaecology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.Senior resident, Department of Obstetrics & Gynaecology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.Professor & Consultant, Department of Obstetrics & Gynaecology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.Associate Professor & Head of Endocrinology department, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.Ex Head of the Department, Consultant & Professor, Department of Obstetrics & Gynaecology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.Introduction: Evidence suggests that by using the classical non pregnant reference range for serum TSH (STSH), one might miss hypothyroidism in pregnancy. Therefore, upper normal cut off value of S TSH should be taken as <2.5 mIU/L in the first trimester and <3mIU/L in the second and third trimester. However, two Indian studies have reported higher trimester specific reference ranges in the Indian pregnant women. Objectives: To assess the maternal and fetal outcomes using new screening criteria with upper S TSH cut off as >3mIU/L, for diagnosing hypothyroidism in pregnancy. Materials and Methods: This study was a cross sectional study, carried out in the Department of Obstetrics and Gynaecology of a tertiary care hospital, in collaboration with the Department of Endocrinology. Pregnant women with ≤ 20 weeks gestation, attending antenatal OPD from December 2010 to January 2012 were included in the study. On the basis of S TSH level, women were divided into Study Group with S TSH level between 3.1 to 6.2 mIU/L, (new range to be studied) and an equal number of age and parity matched Control Group with S TSH levels between 0.4 to 3 mIU/L. The maternal and fetal outcomes were compared between study and control groups. Results: During the study period, a total of 66 women had S TSH between 3.1-6.2 mIU/L. Maternal and fetal outcomes in both the groups were comparable. There was no difference in the mode of delivery between study and control groups. Conclusion: The lower S TSH cut off recommended for diagnosing hypothyroidism in pregnancy may not be applicable to pregnant Indian women.https://jcdr.net/articles/PDF/5735/11106_CE[Ra1]_F(AK)_PF1(AK)_PFA(AK)_PF2(PAG).pdfendocrinological disordersreference valuesscreening in pregnancyserum tsh |
| spellingShingle | Deeksha Joshi Rupali Dewan Rekha Bharti Karishma Thariani Aanchal Sablok Manjula Sharma Krishna Biswas Aruna Batra Feto-maternal Outcome Using New Screening Criteria of Serum TSH for Diagnosing Hypothyroidism in Pregnancy Journal of Clinical and Diagnostic Research endocrinological disorders reference values screening in pregnancy serum tsh |
| title | Feto-maternal Outcome Using New Screening Criteria of Serum TSH for Diagnosing Hypothyroidism in Pregnancy |
| title_full | Feto-maternal Outcome Using New Screening Criteria of Serum TSH for Diagnosing Hypothyroidism in Pregnancy |
| title_fullStr | Feto-maternal Outcome Using New Screening Criteria of Serum TSH for Diagnosing Hypothyroidism in Pregnancy |
| title_full_unstemmed | Feto-maternal Outcome Using New Screening Criteria of Serum TSH for Diagnosing Hypothyroidism in Pregnancy |
| title_short | Feto-maternal Outcome Using New Screening Criteria of Serum TSH for Diagnosing Hypothyroidism in Pregnancy |
| title_sort | feto maternal outcome using new screening criteria of serum tsh for diagnosing hypothyroidism in pregnancy |
| topic | endocrinological disorders reference values screening in pregnancy serum tsh |
| url | https://jcdr.net/articles/PDF/5735/11106_CE[Ra1]_F(AK)_PF1(AK)_PFA(AK)_PF2(PAG).pdf |
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