2,3,4,9-Tetrahydro-9-(3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl)-8-methoxy-3,3-dimethyl-1H-xanthen-1-one
The title compound 2,3,4,9-tetrahydro-9-(3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl)-8-methoxy-3,3-dimethyl-1H-xanthen-1-one (5) was obtained by the nucleophilic addition of 2-hydroxy-1,4-naphthoquinone (4) to 2H-chromene derivative 3, which was prepared by the domino three-component coupling re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-01-01
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| Series: | Molbank |
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| Online Access: | http://www.mdpi.com/1422-8599/2015/1/M841 |
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| author | Eito Yoshioka Shigeru Kohtani Hideto Miyabe |
| author_facet | Eito Yoshioka Shigeru Kohtani Hideto Miyabe |
| author_sort | Eito Yoshioka |
| collection | DOAJ |
| description | The title compound 2,3,4,9-tetrahydro-9-(3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl)-8-methoxy-3,3-dimethyl-1H-xanthen-1-one (5) was obtained by the nucleophilic addition of 2-hydroxy-1,4-naphthoquinone (4) to 2H-chromene derivative 3, which was prepared by the domino three-component coupling reaction of aryne precursor 1 with DMF and the active methylene compound dimedone (2). The one-pot synthesis of the title compound 5 from aryne precursor 1 was also achieved. |
| first_indexed | 2024-12-23T20:08:57Z |
| format | Article |
| id | doaj.art-f9f691b011014990959a28768a04fa48 |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-12-23T20:08:57Z |
| publishDate | 2015-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-f9f691b011014990959a28768a04fa482022-12-21T17:32:51ZengMDPI AGMolbank1422-85992015-01-0120151M84110.3390/M841M8412,3,4,9-Tetrahydro-9-(3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl)-8-methoxy-3,3-dimethyl-1H-xanthen-1-oneEito Yoshioka0Shigeru Kohtani1Hideto Miyabe2School of Pharmacy, Hyogo University of Health Sciences, 1-3-6, Minatojima, Chuo-ku, Kobe, 650-8530, JapanSchool of Pharmacy, Hyogo University of Health Sciences, 1-3-6, Minatojima, Chuo-ku, Kobe, 650-8530, JapanSchool of Pharmacy, Hyogo University of Health Sciences, 1-3-6, Minatojima, Chuo-ku, Kobe, 650-8530, JapanThe title compound 2,3,4,9-tetrahydro-9-(3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl)-8-methoxy-3,3-dimethyl-1H-xanthen-1-one (5) was obtained by the nucleophilic addition of 2-hydroxy-1,4-naphthoquinone (4) to 2H-chromene derivative 3, which was prepared by the domino three-component coupling reaction of aryne precursor 1 with DMF and the active methylene compound dimedone (2). The one-pot synthesis of the title compound 5 from aryne precursor 1 was also achieved.http://www.mdpi.com/1422-8599/2015/1/M841multi-component reactiondomino reactionarynesheterocyclessynthesis |
| spellingShingle | Eito Yoshioka Shigeru Kohtani Hideto Miyabe 2,3,4,9-Tetrahydro-9-(3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl)-8-methoxy-3,3-dimethyl-1H-xanthen-1-one Molbank multi-component reaction domino reaction arynes heterocycles synthesis |
| title | 2,3,4,9-Tetrahydro-9-(3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl)-8-methoxy-3,3-dimethyl-1H-xanthen-1-one |
| title_full | 2,3,4,9-Tetrahydro-9-(3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl)-8-methoxy-3,3-dimethyl-1H-xanthen-1-one |
| title_fullStr | 2,3,4,9-Tetrahydro-9-(3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl)-8-methoxy-3,3-dimethyl-1H-xanthen-1-one |
| title_full_unstemmed | 2,3,4,9-Tetrahydro-9-(3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl)-8-methoxy-3,3-dimethyl-1H-xanthen-1-one |
| title_short | 2,3,4,9-Tetrahydro-9-(3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl)-8-methoxy-3,3-dimethyl-1H-xanthen-1-one |
| title_sort | 2 3 4 9 tetrahydro 9 3 hydroxy 1 4 dioxo 1h dihydro naphthalen 2 yl 8 methoxy 3 3 dimethyl 1h xanthen 1 one |
| topic | multi-component reaction domino reaction arynes heterocycles synthesis |
| url | http://www.mdpi.com/1422-8599/2015/1/M841 |
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