Zika virus induced microcephaly and aberrant hematopoietic cell differentiation modeled in novel neonatal humanized mice

Zika virus induced microcephaly and aberrant hematopoietic cell differentiation modeled in novel neonatal humanized mice

IntroductionImmunocompetent and immunocompromised murine models have been instrumental in answering important questions regarding ZIKV pathogenesis and vertical transmission. However, mimicking human congenital zika syndrome (CZS) characteristics in these murine models has been less than optimal and...

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Bibliographic Details
Main Authors: Kimberly Schmitt, James Z. Curlin, Leila Remling-Mulder, Tawfik Aboellail, Ramesh Akkina
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
humanized mouse model for Zika microcephaly
A dual-purpose hu-mouse model for Zika
Zika virus and hematopoiesis
Zika virus and aberrant B cell development
Neonatal hu-mouse model for Zika
Zika viral effects on human CD34+ HSC
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1060959/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1060959/full

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