Computational analysis of arrhythmogenesis in KCNH2 T618I mutation-associated short QT syndrome and the pharmacological effects of quinidine and sotalol
Abstract Short QT syndrome (SQTS) is a rare but dangerous genetic disease. In this research, we conducted a comprehensive in silico investigation into the arrhythmogenesis in KCNH2 T618I-associated SQTS using a multi-scale human ventricle model. A Markov chain model of I Kr was developed firstly to...
Main Authors: | Shugang Zhang, Weigang Lu, Fei Yang, Zhen Li, Shuang Wang, Mingjian Jiang, Xiaofeng Wang, Zhiqiang Wei |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-11-01
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Series: | npj Systems Biology and Applications |
Online Access: | https://doi.org/10.1038/s41540-022-00254-5 |
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