Computational analysis of arrhythmogenesis in KCNH2 T618I mutation-associated short QT syndrome and the pharmacological effects of quinidine and sotalol

Computational analysis of arrhythmogenesis in KCNH2 T618I mutation-associated short QT syndrome and the pharmacological effects of quinidine and sotalol

Abstract Short QT syndrome (SQTS) is a rare but dangerous genetic disease. In this research, we conducted a comprehensive in silico investigation into the arrhythmogenesis in KCNH2 T618I-associated SQTS using a multi-scale human ventricle model. A Markov chain model of I Kr was developed firstly to...

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Bibliographic Details
Main Authors: Shugang Zhang, Weigang Lu, Fei Yang, Zhen Li, Shuang Wang, Mingjian Jiang, Xiaofeng Wang, Zhiqiang Wei
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-022-00254-5

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