An imported human case with the SARS-CoV-2 Omicron subvariant BA.2.75 in Yunnan Province, China
The Omicron variants spread rapidly worldwide after being initially detected in South Africa in November 2021. It showed increased transmissibility and immune evasion with far more amino acid mutations in the spike (S) protein than the previously circulating variants of concern (VOCs). Notably, on 1...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Biosafety and Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590053622001549 |
| _version_ | 1811293492931985408 |
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| author | Meiling Zhang Zhixiao Chen Jienan Zhou Xiaonan Zhao Yaoyao Chen Yanhong Sun Zhaosheng Liu Wenpeng Gu Chunrui Luo Xiaoqing Fu Xiang Zhao |
| author_facet | Meiling Zhang Zhixiao Chen Jienan Zhou Xiaonan Zhao Yaoyao Chen Yanhong Sun Zhaosheng Liu Wenpeng Gu Chunrui Luo Xiaoqing Fu Xiang Zhao |
| author_sort | Meiling Zhang |
| collection | DOAJ |
| description | The Omicron variants spread rapidly worldwide after being initially detected in South Africa in November 2021. It showed increased transmissibility and immune evasion with far more amino acid mutations in the spike (S) protein than the previously circulating variants of concern (VOCs). Notably, on 15 July 2022, we monitored the first VOC / Omicron subvariant BA.2.75 in China from an imported case. Moreover, nowadays, this subvariant still is predominant in India. It has nine additional mutations in the S protein compared to BA.2, three of which (W152R, G446S, and R493Q reversion) might contribute to higher transmissibility and immune escape. This subvariant could cause wider spread and pose a threat to the global situation. Our timely reporting and continuous genomic analysis are essential to fully elucidate the characteristics of the subvariant BA.2.75 in the future. |
| first_indexed | 2024-04-13T05:02:13Z |
| format | Article |
| id | doaj.art-f9f93c4cc5a44a2985379b1988db3750 |
| institution | Directory Open Access Journal |
| issn | 2590-0536 |
| language | English |
| last_indexed | 2024-04-13T05:02:13Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biosafety and Health |
| spelling | doaj.art-f9f93c4cc5a44a2985379b1988db37502022-12-22T03:01:18ZengElsevierBiosafety and Health2590-05362022-12-0146406409An imported human case with the SARS-CoV-2 Omicron subvariant BA.2.75 in Yunnan Province, ChinaMeiling Zhang0Zhixiao Chen1Jienan Zhou2Xiaonan Zhao3Yaoyao Chen4Yanhong Sun5Zhaosheng Liu6Wenpeng Gu7Chunrui Luo8Xiaoqing Fu9Xiang Zhao10Yunnan Center for Disease Control and Prevention, Kunming 650022, China; Corresponding authors: Yunnan Center for Disease Control and Prevention, Kunming 650022, China (M. Zhang and X. Fu); National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China (X. Zhao).National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaYunnan Center for Disease Control and Prevention, Kunming 650022, ChinaYunnan Center for Disease Control and Prevention, Kunming 650022, ChinaYunnan Center for Disease Control and Prevention, Kunming 650022, ChinaYunnan Center for Disease Control and Prevention, Kunming 650022, ChinaYunnan Center for Disease Control and Prevention, Kunming 650022, ChinaYunnan Center for Disease Control and Prevention, Kunming 650022, ChinaYunnan Center for Disease Control and Prevention, Kunming 650022, ChinaYunnan Center for Disease Control and Prevention, Kunming 650022, China; Corresponding authors: Yunnan Center for Disease Control and Prevention, Kunming 650022, China (M. Zhang and X. Fu); National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China (X. Zhao).National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Corresponding authors: Yunnan Center for Disease Control and Prevention, Kunming 650022, China (M. Zhang and X. Fu); National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China (X. Zhao).The Omicron variants spread rapidly worldwide after being initially detected in South Africa in November 2021. It showed increased transmissibility and immune evasion with far more amino acid mutations in the spike (S) protein than the previously circulating variants of concern (VOCs). Notably, on 15 July 2022, we monitored the first VOC / Omicron subvariant BA.2.75 in China from an imported case. Moreover, nowadays, this subvariant still is predominant in India. It has nine additional mutations in the S protein compared to BA.2, three of which (W152R, G446S, and R493Q reversion) might contribute to higher transmissibility and immune escape. This subvariant could cause wider spread and pose a threat to the global situation. Our timely reporting and continuous genomic analysis are essential to fully elucidate the characteristics of the subvariant BA.2.75 in the future.http://www.sciencedirect.com/science/article/pii/S2590053622001549SARS-CoV-2Omicron subvariantMutationsGenomic analysis |
| spellingShingle | Meiling Zhang Zhixiao Chen Jienan Zhou Xiaonan Zhao Yaoyao Chen Yanhong Sun Zhaosheng Liu Wenpeng Gu Chunrui Luo Xiaoqing Fu Xiang Zhao An imported human case with the SARS-CoV-2 Omicron subvariant BA.2.75 in Yunnan Province, China Biosafety and Health SARS-CoV-2 Omicron subvariant Mutations Genomic analysis |
| title | An imported human case with the SARS-CoV-2 Omicron subvariant BA.2.75 in Yunnan Province, China |
| title_full | An imported human case with the SARS-CoV-2 Omicron subvariant BA.2.75 in Yunnan Province, China |
| title_fullStr | An imported human case with the SARS-CoV-2 Omicron subvariant BA.2.75 in Yunnan Province, China |
| title_full_unstemmed | An imported human case with the SARS-CoV-2 Omicron subvariant BA.2.75 in Yunnan Province, China |
| title_short | An imported human case with the SARS-CoV-2 Omicron subvariant BA.2.75 in Yunnan Province, China |
| title_sort | imported human case with the sars cov 2 omicron subvariant ba 2 75 in yunnan province china |
| topic | SARS-CoV-2 Omicron subvariant Mutations Genomic analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2590053622001549 |
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