Overdose intake of Neu5Gc triggers colorectal inflammation and alters liver metabolism
ABSTRACTA positive correlation between massive red meat consumption with colorectal cancer had been reported. Given the complexity of meat components, we focused on investigating the role of Neu5Gc in human healthy. Two groups, either feeding with normal and overdose concentration of Neu5Gc for two...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Food and Agricultural Immunology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/09540105.2023.2281274 |
| _version_ | 1827630181872828416 |
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| author | Teng Yuan Peidong Yang Anjing Zhang Jing Li Ziyin Han Shuqi Yang Yihamu Jimu Fanli Kong Dengke Pan Keren Long Mingzhou Li Lu Lu |
| author_facet | Teng Yuan Peidong Yang Anjing Zhang Jing Li Ziyin Han Shuqi Yang Yihamu Jimu Fanli Kong Dengke Pan Keren Long Mingzhou Li Lu Lu |
| author_sort | Teng Yuan |
| collection | DOAJ |
| description | ABSTRACTA positive correlation between massive red meat consumption with colorectal cancer had been reported. Given the complexity of meat components, we focused on investigating the role of Neu5Gc in human healthy. Two groups, either feeding with normal and overdose concentration of Neu5Gc for two weeks, to mimic the normal and overconsumption of red meat conditions in human, respectively. The colorectal transcriptomes revealed that Neu5Gc promotes intestinal immune response and identified the hub genes positively correlated with colorectal cancer such as Tnf, Cd19, Muc13, and Nso2,. The colorectal cancer patients have a 25–30% chance of developing liver metastases, thus we sequenced the liver and revealed the role of Neu5Gc in regulating cell metabolism. Moreover, we found that Neu5Gc negatively regulates the expression of Cmah. We conclude that high Neu5Gc intake promotes colorectal inflammatory responses in ApcMin/+ mice, and suppresses colorectal and hepatic metabolic and digestive processes through Cmah inhibition. |
| first_indexed | 2024-03-09T14:02:29Z |
| format | Article |
| id | doaj.art-f9faab867fa2465ca09eadda99e05af5 |
| institution | Directory Open Access Journal |
| issn | 0954-0105 1465-3443 |
| language | English |
| last_indexed | 2024-03-09T14:02:29Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Food and Agricultural Immunology |
| spelling | doaj.art-f9faab867fa2465ca09eadda99e05af52023-11-30T06:57:34ZengTaylor & Francis GroupFood and Agricultural Immunology0954-01051465-34432023-12-0134110.1080/09540105.2023.2281274Overdose intake of Neu5Gc triggers colorectal inflammation and alters liver metabolismTeng Yuan0Peidong Yang1Anjing Zhang2Jing Li3Ziyin Han4Shuqi Yang5Yihamu Jimu6Fanli Kong7Dengke Pan8Keren Long9Mingzhou Li10Lu Lu11State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, People’s Republic of ChinaState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, People’s Republic of ChinaState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, People’s Republic of ChinaState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, People’s Republic of ChinaState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, People’s Republic of ChinaState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, People’s Republic of ChinaState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, People’s Republic of ChinaCollege of Life Science, Sichuan Agricultural University, Ya'an, People’s Republic of ChinaClinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, People’s Republic of ChinaState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, People’s Republic of ChinaState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, People’s Republic of ChinaState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, People’s Republic of ChinaABSTRACTA positive correlation between massive red meat consumption with colorectal cancer had been reported. Given the complexity of meat components, we focused on investigating the role of Neu5Gc in human healthy. Two groups, either feeding with normal and overdose concentration of Neu5Gc for two weeks, to mimic the normal and overconsumption of red meat conditions in human, respectively. The colorectal transcriptomes revealed that Neu5Gc promotes intestinal immune response and identified the hub genes positively correlated with colorectal cancer such as Tnf, Cd19, Muc13, and Nso2,. The colorectal cancer patients have a 25–30% chance of developing liver metastases, thus we sequenced the liver and revealed the role of Neu5Gc in regulating cell metabolism. Moreover, we found that Neu5Gc negatively regulates the expression of Cmah. We conclude that high Neu5Gc intake promotes colorectal inflammatory responses in ApcMin/+ mice, and suppresses colorectal and hepatic metabolic and digestive processes through Cmah inhibition.https://www.tandfonline.com/doi/10.1080/09540105.2023.2281274Apcmin/+ mousecolorectal cancerNeu5Gctranscriptome |
| spellingShingle | Teng Yuan Peidong Yang Anjing Zhang Jing Li Ziyin Han Shuqi Yang Yihamu Jimu Fanli Kong Dengke Pan Keren Long Mingzhou Li Lu Lu Overdose intake of Neu5Gc triggers colorectal inflammation and alters liver metabolism Food and Agricultural Immunology Apcmin/+ mouse colorectal cancer Neu5Gc transcriptome |
| title | Overdose intake of Neu5Gc triggers colorectal inflammation and alters liver metabolism |
| title_full | Overdose intake of Neu5Gc triggers colorectal inflammation and alters liver metabolism |
| title_fullStr | Overdose intake of Neu5Gc triggers colorectal inflammation and alters liver metabolism |
| title_full_unstemmed | Overdose intake of Neu5Gc triggers colorectal inflammation and alters liver metabolism |
| title_short | Overdose intake of Neu5Gc triggers colorectal inflammation and alters liver metabolism |
| title_sort | overdose intake of neu5gc triggers colorectal inflammation and alters liver metabolism |
| topic | Apcmin/+ mouse colorectal cancer Neu5Gc transcriptome |
| url | https://www.tandfonline.com/doi/10.1080/09540105.2023.2281274 |
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