Design rules for selective binding of nuclear localization signals to minor site of importin α.
Selectivity is a critical issue in molecular recognition. However, design rules that underlie selectivity are often not well understood. Here, we studied five classical nuclear localization signals (NLSs) that contain the motif KRx(W/F/Y)xxAF and selectively bind to the minor site of importin α. The...
| المؤلفون الرئيسيون: | , |
|---|---|
| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
Public Library of Science (PLoS)
2014-01-01
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| سلاسل: | PLoS ONE |
| الوصول للمادة أونلاين: | http://europepmc.org/articles/PMC3946659?pdf=render |