Design rules for selective binding of nuclear localization signals to minor site of importin α.

Design rules for selective binding of nuclear localization signals to minor site of importin α.

Selectivity is a critical issue in molecular recognition. However, design rules that underlie selectivity are often not well understood. Here, we studied five classical nuclear localization signals (NLSs) that contain the motif KRx(W/F/Y)xxAF and selectively bind to the minor site of importin α. The...

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Dades bibliogràfiques
Autors principals:	Xiaodong Pang, Huan-Xiang Zhou
Format:	Article
Idioma:	English
Publicat:	Public Library of Science (PLoS) 2014-01-01
Col·lecció:	PLoS ONE
Accés en línia:	http://europepmc.org/articles/PMC3946659?pdf=render

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