Design rules for selective binding of nuclear localization signals to minor site of importin α.

Design rules for selective binding of nuclear localization signals to minor site of importin α.

Selectivity is a critical issue in molecular recognition. However, design rules that underlie selectivity are often not well understood. Here, we studied five classical nuclear localization signals (NLSs) that contain the motif KRx(W/F/Y)xxAF and selectively bind to the minor site of importin α. The...

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Manylion Llyfryddiaeth
Prif Awduron:	Xiaodong Pang, Huan-Xiang Zhou
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	Public Library of Science (PLoS) 2014-01-01
Cyfres:	PLoS ONE
Mynediad Ar-lein:	http://europepmc.org/articles/PMC3946659?pdf=render

Eitemau Tebyg

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Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α
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