Design rules for selective binding of nuclear localization signals to minor site of importin α.

Design rules for selective binding of nuclear localization signals to minor site of importin α.

Selectivity is a critical issue in molecular recognition. However, design rules that underlie selectivity are often not well understood. Here, we studied five classical nuclear localization signals (NLSs) that contain the motif KRx(W/F/Y)xxAF and selectively bind to the minor site of importin α. The...

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Bibliographische Detailangaben
Hauptverfasser: Xiaodong Pang, Huan-Xiang Zhou
Format: Artikel
Sprache:English
Veröffentlicht: Public Library of Science (PLoS) 2014-01-01
Schriftenreihe:PLoS ONE
Online Zugang:http://europepmc.org/articles/PMC3946659?pdf=render

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