Design rules for selective binding of nuclear localization signals to minor site of importin α.

Design rules for selective binding of nuclear localization signals to minor site of importin α.

Selectivity is a critical issue in molecular recognition. However, design rules that underlie selectivity are often not well understood. Here, we studied five classical nuclear localization signals (NLSs) that contain the motif KRx(W/F/Y)xxAF and selectively bind to the minor site of importin α. The...

Bibliografski detalji
Glavni autori:	Xiaodong Pang, Huan-Xiang Zhou
Format:	Članak
Jezik:	English
Izdano:	Public Library of Science (PLoS) 2014-01-01
Serija:	PLoS ONE
Online pristup:	http://europepmc.org/articles/PMC3946659?pdf=render

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