Design rules for selective binding of nuclear localization signals to minor site of importin α.

Design rules for selective binding of nuclear localization signals to minor site of importin α.

Selectivity is a critical issue in molecular recognition. However, design rules that underlie selectivity are often not well understood. Here, we studied five classical nuclear localization signals (NLSs) that contain the motif KRx(W/F/Y)xxAF and selectively bind to the minor site of importin α. The...

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Dettagli Bibliografici
Autori principali:	Xiaodong Pang, Huan-Xiang Zhou
Natura:	Articolo
Lingua:	English
Pubblicazione:	Public Library of Science (PLoS) 2014-01-01
Serie:	PLoS ONE
Accesso online:	http://europepmc.org/articles/PMC3946659?pdf=render

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