Design rules for selective binding of nuclear localization signals to minor site of importin α.

Design rules for selective binding of nuclear localization signals to minor site of importin α.

Selectivity is a critical issue in molecular recognition. However, design rules that underlie selectivity are often not well understood. Here, we studied five classical nuclear localization signals (NLSs) that contain the motif KRx(W/F/Y)xxAF and selectively bind to the minor site of importin α. The...

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Bibliografiska uppgifter
Huvudupphovsmän: Xiaodong Pang, Huan-Xiang Zhou
Materialtyp: Artikel
Språk:English
Publicerad: Public Library of Science (PLoS) 2014-01-01
Serie:PLoS ONE
Länkar:http://europepmc.org/articles/PMC3946659?pdf=render

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