Transcriptional Circuits Regulating Developmental Processes in Candida albicans
Candida albicans is a commensal member of the human microbiota that colonizes multiple niches in the body including the skin, oral cavity, and gastrointestinal and genitourinary tracts of healthy individuals. It is also the most common human fungal pathogen isolated from patients in clinical setting...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2020.605711/full |
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| author | Diana L. Rodriguez Diana L. Rodriguez Morgan M. Quail Morgan M. Quail Aaron D. Hernday Aaron D. Hernday Clarissa J. Nobile Clarissa J. Nobile |
| author_facet | Diana L. Rodriguez Diana L. Rodriguez Morgan M. Quail Morgan M. Quail Aaron D. Hernday Aaron D. Hernday Clarissa J. Nobile Clarissa J. Nobile |
| author_sort | Diana L. Rodriguez |
| collection | DOAJ |
| description | Candida albicans is a commensal member of the human microbiota that colonizes multiple niches in the body including the skin, oral cavity, and gastrointestinal and genitourinary tracts of healthy individuals. It is also the most common human fungal pathogen isolated from patients in clinical settings. C. albicans can cause a number of superficial and invasive infections, especially in immunocompromised individuals. The ability of C. albicans to succeed as both a commensal and a pathogen, and to thrive in a wide range of environmental niches within the host, requires sophisticated transcriptional regulatory programs that can integrate and respond to host specific environmental signals. Identifying and characterizing the transcriptional regulatory networks that control important developmental processes in C. albicans will shed new light on the strategies used by C. albicans to colonize and infect its host. Here, we discuss the transcriptional regulatory circuits controlling three major developmental processes in C. albicans: biofilm formation, the white-opaque phenotypic switch, and the commensal-pathogen transition. Each of these three circuits are tightly knit and, through our analyses, we show that they are integrated together by extensive regulatory crosstalk between the core regulators that comprise each circuit. |
| first_indexed | 2024-12-20T01:08:52Z |
| format | Article |
| id | doaj.art-f9fb9ac62c054d9abad91db3f9478574 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-20T01:08:52Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-f9fb9ac62c054d9abad91db3f94785742022-12-21T19:58:45ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882020-12-011010.3389/fcimb.2020.605711605711Transcriptional Circuits Regulating Developmental Processes in Candida albicansDiana L. Rodriguez0Diana L. Rodriguez1Morgan M. Quail2Morgan M. Quail3Aaron D. Hernday4Aaron D. Hernday5Clarissa J. Nobile6Clarissa J. Nobile7Department of Molecular and Cell Biology, School of Natural Sciences, University of California—Merced, Merced, CA, United StatesQuantitative and Systems Biology Graduate Program, University of California—Merced, Merced, CA, United StatesDepartment of Molecular and Cell Biology, School of Natural Sciences, University of California—Merced, Merced, CA, United StatesQuantitative and Systems Biology Graduate Program, University of California—Merced, Merced, CA, United StatesDepartment of Molecular and Cell Biology, School of Natural Sciences, University of California—Merced, Merced, CA, United StatesHealth Sciences Research Institute, University of California - Merced, Merced, CA, United StatesDepartment of Molecular and Cell Biology, School of Natural Sciences, University of California—Merced, Merced, CA, United StatesHealth Sciences Research Institute, University of California - Merced, Merced, CA, United StatesCandida albicans is a commensal member of the human microbiota that colonizes multiple niches in the body including the skin, oral cavity, and gastrointestinal and genitourinary tracts of healthy individuals. It is also the most common human fungal pathogen isolated from patients in clinical settings. C. albicans can cause a number of superficial and invasive infections, especially in immunocompromised individuals. The ability of C. albicans to succeed as both a commensal and a pathogen, and to thrive in a wide range of environmental niches within the host, requires sophisticated transcriptional regulatory programs that can integrate and respond to host specific environmental signals. Identifying and characterizing the transcriptional regulatory networks that control important developmental processes in C. albicans will shed new light on the strategies used by C. albicans to colonize and infect its host. Here, we discuss the transcriptional regulatory circuits controlling three major developmental processes in C. albicans: biofilm formation, the white-opaque phenotypic switch, and the commensal-pathogen transition. Each of these three circuits are tightly knit and, through our analyses, we show that they are integrated together by extensive regulatory crosstalk between the core regulators that comprise each circuit.https://www.frontiersin.org/articles/10.3389/fcimb.2020.605711/fullCandida albicansbiofilmscommensal-pathogen transitiontranscriptional regulationtranscriptional networkstranscriptional rewiring |
| spellingShingle | Diana L. Rodriguez Diana L. Rodriguez Morgan M. Quail Morgan M. Quail Aaron D. Hernday Aaron D. Hernday Clarissa J. Nobile Clarissa J. Nobile Transcriptional Circuits Regulating Developmental Processes in Candida albicans Frontiers in Cellular and Infection Microbiology Candida albicans biofilms commensal-pathogen transition transcriptional regulation transcriptional networks transcriptional rewiring |
| title | Transcriptional Circuits Regulating Developmental Processes in Candida albicans |
| title_full | Transcriptional Circuits Regulating Developmental Processes in Candida albicans |
| title_fullStr | Transcriptional Circuits Regulating Developmental Processes in Candida albicans |
| title_full_unstemmed | Transcriptional Circuits Regulating Developmental Processes in Candida albicans |
| title_short | Transcriptional Circuits Regulating Developmental Processes in Candida albicans |
| title_sort | transcriptional circuits regulating developmental processes in candida albicans |
| topic | Candida albicans biofilms commensal-pathogen transition transcriptional regulation transcriptional networks transcriptional rewiring |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2020.605711/full |
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