An emerging role for adenosine and its receptors in bone homeostasis
Bone is continually being remodelled and defects in the processes involved lead to bone diseases. Many regulatory factors are known to influence remodelling but other mechanisms, hitherto unknown, may also be involved. Importantly, our understanding of these currently unknown mechanisms may lead to...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-09-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00113/full |
| _version_ | 1819232155145863168 |
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| author | Bronwen eEvans Bronwen eEvans Jack eHam Jack eHam |
| author_facet | Bronwen eEvans Bronwen eEvans Jack eHam Jack eHam |
| author_sort | Bronwen eEvans |
| collection | DOAJ |
| description | Bone is continually being remodelled and defects in the processes involved lead to bone diseases. Many regulatory factors are known to influence remodelling but other mechanisms, hitherto unknown, may also be involved. Importantly, our understanding of these currently unknown mechanisms may lead to important new therapies for bone disease. It is accepted that purinergic signalling is involved in bone, and our knowledge of this area has increased significantly over the last fifteen years, although most of the published work has studied the role of ATP and other signalling molecules via the P2 family of purinergic receptors. During the last few years, however, there has been increased interest within the bone field in the role of P1 receptors where adenosine is the primary signalling molecule. This review will bring together the current information available in relation to this expanding area of research. |
| first_indexed | 2024-12-23T11:56:21Z |
| format | Article |
| id | doaj.art-f9fccc5ea8784a83a9e802113a1a86ed |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-23T11:56:21Z |
| publishDate | 2012-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-f9fccc5ea8784a83a9e802113a1a86ed2022-12-21T17:48:04ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922012-09-01310.3389/fendo.2012.0011330507An emerging role for adenosine and its receptors in bone homeostasisBronwen eEvans0Bronwen eEvans1Jack eHam2Jack eHam3Cardiff UniversityCardiff Institute for Tissue Engineering and RepairCardiff UniversityCardiff Institute for Tissue Engineering and RepairBone is continually being remodelled and defects in the processes involved lead to bone diseases. Many regulatory factors are known to influence remodelling but other mechanisms, hitherto unknown, may also be involved. Importantly, our understanding of these currently unknown mechanisms may lead to important new therapies for bone disease. It is accepted that purinergic signalling is involved in bone, and our knowledge of this area has increased significantly over the last fifteen years, although most of the published work has studied the role of ATP and other signalling molecules via the P2 family of purinergic receptors. During the last few years, however, there has been increased interest within the bone field in the role of P1 receptors where adenosine is the primary signalling molecule. This review will bring together the current information available in relation to this expanding area of research.http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00113/fullAdenosineMesenchymal Stem CellsMetabolismOsteoblastsOsteoclastsBone |
| spellingShingle | Bronwen eEvans Bronwen eEvans Jack eHam Jack eHam An emerging role for adenosine and its receptors in bone homeostasis Frontiers in Endocrinology Adenosine Mesenchymal Stem Cells Metabolism Osteoblasts Osteoclasts Bone |
| title | An emerging role for adenosine and its receptors in bone homeostasis |
| title_full | An emerging role for adenosine and its receptors in bone homeostasis |
| title_fullStr | An emerging role for adenosine and its receptors in bone homeostasis |
| title_full_unstemmed | An emerging role for adenosine and its receptors in bone homeostasis |
| title_short | An emerging role for adenosine and its receptors in bone homeostasis |
| title_sort | emerging role for adenosine and its receptors in bone homeostasis |
| topic | Adenosine Mesenchymal Stem Cells Metabolism Osteoblasts Osteoclasts Bone |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00113/full |
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