Shank3 deficiency elicits autistic-like behaviors by activating p38α in hypothalamic AgRP neurons

Shank3 deficiency elicits autistic-like behaviors by activating p38α in hypothalamic AgRP neurons

Abstract Background SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) monogenic mutations or deficiency leads to excessive stereotypic behavior and impaired sociability, which frequently occur in autism cases. To date, the underlying mechanisms by which Shank3 mutation or deletion causes au...

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Main Authors: Shanshan Wu, Jing Wang, Zicheng Zhang, Xinchen Jin, Yang Xu, Youwen Si, Yixiao Liang, Yueping Ge, Huidong Zhan, Li peng, Wenkai Bi, Dandan Luo, Mengzhu Li, Bo Meng, Qingbo Guan, Jiajun Zhao, Ling Gao, Zhao He
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Molecular Autism
Subjects:
Autism
p38α
SHANK3
AgRP
Stereotypic behavior
Sociability
Online Access:https://doi.org/10.1186/s13229-024-00595-4

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