Toll 7 and Toll 9 in psoriasis vulgaris before and after phototherapy
Introduction: Psoriasis is a common chronic inflammatory, recurrent, immune mediated disease of the skin and joints. Toll-like receptors are pattern recognition receptors for conserved molecular patterns of pathogenic microorganisms.Under certain circumstances, self nucleic acids can trigger TLR 7 a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Our Dermatology Online
2014-04-01
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| Series: | Nasza Dermatologia Online |
| Subjects: | |
| Online Access: | http://www.odermatol.com/issue-in-html/2014-2-5-toll/ |
| _version_ | 1818661835078893568 |
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| author | Doaa Mahgoub Amira M. El Tawdy Mariam Makari Laila Rashed |
| author_facet | Doaa Mahgoub Amira M. El Tawdy Mariam Makari Laila Rashed |
| author_sort | Doaa Mahgoub |
| collection | DOAJ |
| description | Introduction: Psoriasis is a common chronic inflammatory, recurrent, immune mediated disease of the skin and joints. Toll-like receptors are pattern recognition receptors for conserved molecular patterns of pathogenic microorganisms.Under certain circumstances, self nucleic acids can trigger TLR 7 and TLR 9, which can lead to autoimmune diseases such as psoriasis.
Materials and Methods: The study included 15 psoriatic patients (plaque type) and 15 controls, patients received 36 sessions of phototherapy (NB-UVB). Skin biopsies were taken from all the patients (before & after NB-UVB) and controls and were assessed for TLR 7 and TLR 9 by PCR.
Results: Showed significant difference between patients and controls as regards TLR 7 and TLR 9. In addition a significant decrease in thier levels in patients after phototherapy with NB-UVB.
Conclusion: TLR 7 and TLR 9 may play a role in the pathogenesis of poriasis. Decrease in their levels after NB-UVB may be one of the therapeutic mechanisms of NB-UVB in psoriasis. |
| first_indexed | 2024-12-17T04:51:22Z |
| format | Article |
| id | doaj.art-f9fe3c81fa8a4b3caa40fd82d88c5fe9 |
| institution | Directory Open Access Journal |
| issn | 2081-9390 |
| language | English |
| last_indexed | 2024-12-17T04:51:22Z |
| publishDate | 2014-04-01 |
| publisher | Our Dermatology Online |
| record_format | Article |
| series | Nasza Dermatologia Online |
| spelling | doaj.art-f9fe3c81fa8a4b3caa40fd82d88c5fe92022-12-21T22:02:53ZengOur Dermatology OnlineNasza Dermatologia Online2081-93902014-04-015212913410.7241/ourd.20142.31Toll 7 and Toll 9 in psoriasis vulgaris before and after phototherapyDoaa Mahgoub0Amira M. El Tawdy1Mariam Makari2Laila Rashed3Department of Dermatology, Kasr Aini Hospital, Cairo University, Egypt Department of Dermatology, Kasr Aini Hospital, Cairo University, Egypt Department of Dermatology, Kasr Aini Hospital, Cairo University, Egypt Department of Biochemistry, Kasr Aini Hospital, Cairo University, EgyptIntroduction: Psoriasis is a common chronic inflammatory, recurrent, immune mediated disease of the skin and joints. Toll-like receptors are pattern recognition receptors for conserved molecular patterns of pathogenic microorganisms.Under certain circumstances, self nucleic acids can trigger TLR 7 and TLR 9, which can lead to autoimmune diseases such as psoriasis. Materials and Methods: The study included 15 psoriatic patients (plaque type) and 15 controls, patients received 36 sessions of phototherapy (NB-UVB). Skin biopsies were taken from all the patients (before & after NB-UVB) and controls and were assessed for TLR 7 and TLR 9 by PCR. Results: Showed significant difference between patients and controls as regards TLR 7 and TLR 9. In addition a significant decrease in thier levels in patients after phototherapy with NB-UVB. Conclusion: TLR 7 and TLR 9 may play a role in the pathogenesis of poriasis. Decrease in their levels after NB-UVB may be one of the therapeutic mechanisms of NB-UVB in psoriasis.http://www.odermatol.com/issue-in-html/2014-2-5-toll/PsoriasisToll-like receptors 7 and 9NB-UVB |
| spellingShingle | Doaa Mahgoub Amira M. El Tawdy Mariam Makari Laila Rashed Toll 7 and Toll 9 in psoriasis vulgaris before and after phototherapy Nasza Dermatologia Online Psoriasis Toll-like receptors 7 and 9 NB-UVB |
| title | Toll 7 and Toll 9 in psoriasis vulgaris before and after phototherapy |
| title_full | Toll 7 and Toll 9 in psoriasis vulgaris before and after phototherapy |
| title_fullStr | Toll 7 and Toll 9 in psoriasis vulgaris before and after phototherapy |
| title_full_unstemmed | Toll 7 and Toll 9 in psoriasis vulgaris before and after phototherapy |
| title_short | Toll 7 and Toll 9 in psoriasis vulgaris before and after phototherapy |
| title_sort | toll 7 and toll 9 in psoriasis vulgaris before and after phototherapy |
| topic | Psoriasis Toll-like receptors 7 and 9 NB-UVB |
| url | http://www.odermatol.com/issue-in-html/2014-2-5-toll/ |
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