Uterine macrophages as treatment targets for therapy of premature rupture of membranes by modified ADSC-EVs through a circRNA/miRNA/NF-κB pathway

Uterine macrophages as treatment targets for therapy of premature rupture of membranes by modified ADSC-EVs through a circRNA/miRNA/NF-κB pathway

Abstract Background Circular RNA (circRNA) is a type of stable non-coding RNA that modifies macrophage inflammation by sponging micro RNAs (miRNAs), binding to RNA-binding proteins, and undergoing translation into peptides. Activated M1 phenotype macrophages secrete matrix metalloproteinases to part...

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Bibliographic Details
Main Authors: Yuhua Gao, Ningning Mi, Ying Zhang, Xiangchen Li, Weijun Guan, Chunyu Bai
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Nanobiotechnology
Subjects:
PROM
MMPs
Macrophages
ADSCs
Extracellular vesicles
Online Access:https://doi.org/10.1186/s12951-022-01696-z

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