The Diagnostic Potential of Amyloidogenic Proteins
Neurodegenerative disorders are a highly prevalent class of diseases, whose pathological mechanisms start before the appearance of any clear symptoms. This fact has prompted scientists to search for biomarkers that could aid early treatment. These currently incurable pathologies share the presence o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/8/4128 |
| _version_ | 1797537492821344256 |
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| author | Yiyun Jin Devkee Mahesh Vadukul Dimitra Gialama Ying Ge Rebecca Thrush Joe Thomas White Francesco Antonio Aprile |
| author_facet | Yiyun Jin Devkee Mahesh Vadukul Dimitra Gialama Ying Ge Rebecca Thrush Joe Thomas White Francesco Antonio Aprile |
| author_sort | Yiyun Jin |
| collection | DOAJ |
| description | Neurodegenerative disorders are a highly prevalent class of diseases, whose pathological mechanisms start before the appearance of any clear symptoms. This fact has prompted scientists to search for biomarkers that could aid early treatment. These currently incurable pathologies share the presence of aberrant aggregates called amyloids in the nervous system, which are composed of specific proteins. In this review, we discuss how these proteins, their conformations and modifications could be exploited as biomarkers for diagnostic purposes. We focus on proteins that are associated with the most prevalent neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases, amyotrophic lateral sclerosis, and frontotemporal dementia. We also describe current challenges in detection, the most recent techniques with diagnostic potentials and possible future developments in diagnosis. |
| first_indexed | 2024-03-10T12:15:58Z |
| format | Article |
| id | doaj.art-f9fffe71e60c4cb0b7b0432f5622eac7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:15:58Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f9fffe71e60c4cb0b7b0432f5622eac72023-11-21T15:52:32ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01228412810.3390/ijms22084128The Diagnostic Potential of Amyloidogenic ProteinsYiyun Jin0Devkee Mahesh Vadukul1Dimitra Gialama2Ying Ge3Rebecca Thrush4Joe Thomas White5Francesco Antonio Aprile6Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UKDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UKDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UKDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UKDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UKDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UKDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UKNeurodegenerative disorders are a highly prevalent class of diseases, whose pathological mechanisms start before the appearance of any clear symptoms. This fact has prompted scientists to search for biomarkers that could aid early treatment. These currently incurable pathologies share the presence of aberrant aggregates called amyloids in the nervous system, which are composed of specific proteins. In this review, we discuss how these proteins, their conformations and modifications could be exploited as biomarkers for diagnostic purposes. We focus on proteins that are associated with the most prevalent neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases, amyotrophic lateral sclerosis, and frontotemporal dementia. We also describe current challenges in detection, the most recent techniques with diagnostic potentials and possible future developments in diagnosis.https://www.mdpi.com/1422-0067/22/8/4128neurodegenerative diseasesbiomarkeramyloidoligomerpost-translational modification |
| spellingShingle | Yiyun Jin Devkee Mahesh Vadukul Dimitra Gialama Ying Ge Rebecca Thrush Joe Thomas White Francesco Antonio Aprile The Diagnostic Potential of Amyloidogenic Proteins International Journal of Molecular Sciences neurodegenerative diseases biomarker amyloid oligomer post-translational modification |
| title | The Diagnostic Potential of Amyloidogenic Proteins |
| title_full | The Diagnostic Potential of Amyloidogenic Proteins |
| title_fullStr | The Diagnostic Potential of Amyloidogenic Proteins |
| title_full_unstemmed | The Diagnostic Potential of Amyloidogenic Proteins |
| title_short | The Diagnostic Potential of Amyloidogenic Proteins |
| title_sort | diagnostic potential of amyloidogenic proteins |
| topic | neurodegenerative diseases biomarker amyloid oligomer post-translational modification |
| url | https://www.mdpi.com/1422-0067/22/8/4128 |
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