Alzheimer’s Disease: Causal Effect between Obesity and APOE Gene Polymorphisms
Currently studies on the correlation between obesity and Alzheimer’s disease (AD) are still unclear. In addition, few indicators have been used to evaluate obesity, which has failed to comprehen-sively study the correlations between body fat mass, body fat distribution, and AD. Thus, this study inno...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/17/13531 |
| _version_ | 1797582428409167872 |
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| author | Tianyu Zhao Tangsheng Zhong Meishuang Zhang Yang Xu Ming Zhang Li Chen |
| author_facet | Tianyu Zhao Tangsheng Zhong Meishuang Zhang Yang Xu Ming Zhang Li Chen |
| author_sort | Tianyu Zhao |
| collection | DOAJ |
| description | Currently studies on the correlation between obesity and Alzheimer’s disease (AD) are still unclear. In addition, few indicators have been used to evaluate obesity, which has failed to comprehen-sively study the correlations between body fat mass, body fat distribution, and AD. Thus, this study innovatively utilized bioinformatics and Mendelian randomization (MR) to explore the key targets of obesity-induced AD, and investigate the causal associations between different types of obesity and key targets. The common targets of obesity and AD were screened using the GeneCards database, and functional and pathway annotations were carried out, thereby revealing the key target. MR analysis was conducted between body anthropometric indexes of obesity and the key target using an IVW model. Bioinformatics analysis revealed Apolipoprotein E (APOE) as the key target of obesity-induced AD. MR results showed that body mass index (BMI) had a negative causal association with APOE2, while body fat percentage (BFP) and trunk fat percentage (TFP) had no significant causal association with APOE2; BMI, BFP, and TFP had a negative causal association with APOE3, and none had any significant causal association with APOE4. In conclusion, there is a correlation between obesity and AD, which is mainly due to the polymorphism of the APOE gene rather than adipose tissue distribution. APOE3 carriers may be more susceptible to obesity, while the risk of AD caused by APOE2 and APOE4 may not be induced by obesity. This study sheds new light on current disputes. At the same time, it is suggested to regulate the body fat mass of APOE3 carriers in the early stage, and to reduce the risk of AD. |
| first_indexed | 2024-03-10T23:21:03Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:21:03Z |
| publishDate | 2023-08-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fa01b326ec474622b5740ee14d54e3192023-11-19T08:18:36ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124171353110.3390/ijms241713531Alzheimer’s Disease: Causal Effect between Obesity and APOE Gene PolymorphismsTianyu Zhao0Tangsheng Zhong1Meishuang Zhang2Yang Xu3Ming Zhang4Li Chen5Department of Pharmacology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130012, ChinaSchool of Nursing, Jilin University, 965 Xinjiang Street, Changchun 130012, ChinaSchool of Nursing, Jilin University, 965 Xinjiang Street, Changchun 130012, ChinaDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130012, ChinaDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130012, ChinaDepartment of Pharmacology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130012, ChinaCurrently studies on the correlation between obesity and Alzheimer’s disease (AD) are still unclear. In addition, few indicators have been used to evaluate obesity, which has failed to comprehen-sively study the correlations between body fat mass, body fat distribution, and AD. Thus, this study innovatively utilized bioinformatics and Mendelian randomization (MR) to explore the key targets of obesity-induced AD, and investigate the causal associations between different types of obesity and key targets. The common targets of obesity and AD were screened using the GeneCards database, and functional and pathway annotations were carried out, thereby revealing the key target. MR analysis was conducted between body anthropometric indexes of obesity and the key target using an IVW model. Bioinformatics analysis revealed Apolipoprotein E (APOE) as the key target of obesity-induced AD. MR results showed that body mass index (BMI) had a negative causal association with APOE2, while body fat percentage (BFP) and trunk fat percentage (TFP) had no significant causal association with APOE2; BMI, BFP, and TFP had a negative causal association with APOE3, and none had any significant causal association with APOE4. In conclusion, there is a correlation between obesity and AD, which is mainly due to the polymorphism of the APOE gene rather than adipose tissue distribution. APOE3 carriers may be more susceptible to obesity, while the risk of AD caused by APOE2 and APOE4 may not be induced by obesity. This study sheds new light on current disputes. At the same time, it is suggested to regulate the body fat mass of APOE3 carriers in the early stage, and to reduce the risk of AD.https://www.mdpi.com/1422-0067/24/17/13531obesityAlzheimer’s diseaseAPOE gene polymorphismsMendelian randomizationcausal association |
| spellingShingle | Tianyu Zhao Tangsheng Zhong Meishuang Zhang Yang Xu Ming Zhang Li Chen Alzheimer’s Disease: Causal Effect between Obesity and APOE Gene Polymorphisms International Journal of Molecular Sciences obesity Alzheimer’s disease APOE gene polymorphisms Mendelian randomization causal association |
| title | Alzheimer’s Disease: Causal Effect between Obesity and APOE Gene Polymorphisms |
| title_full | Alzheimer’s Disease: Causal Effect between Obesity and APOE Gene Polymorphisms |
| title_fullStr | Alzheimer’s Disease: Causal Effect between Obesity and APOE Gene Polymorphisms |
| title_full_unstemmed | Alzheimer’s Disease: Causal Effect between Obesity and APOE Gene Polymorphisms |
| title_short | Alzheimer’s Disease: Causal Effect between Obesity and APOE Gene Polymorphisms |
| title_sort | alzheimer s disease causal effect between obesity and apoe gene polymorphisms |
| topic | obesity Alzheimer’s disease APOE gene polymorphisms Mendelian randomization causal association |
| url | https://www.mdpi.com/1422-0067/24/17/13531 |
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