Total Asymmetric Synthesis of Monosaccharides and Analogues
Since the discovery of the 'formose reaction' by Butlerow,[1] total synthesis of carbohydrates has undergone rapid development. The most important methods for the asymmetric synthesis of monosaccharides and analogues of biological importance are presented. Nowadays any natural an...
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2011-02-01
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| Series: | CHIMIA |
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| Online Access: | https://www.chimia.ch/chimia/article/view/4965 |
| _version_ | 1819278715999223808 |
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| author | Inmaculada Robina Ana T. Carmona Antonio J. Moreno-Vargas Elena Moreno-Clavijo |
| author_facet | Inmaculada Robina Ana T. Carmona Antonio J. Moreno-Vargas Elena Moreno-Clavijo |
| author_sort | Inmaculada Robina |
| collection | DOAJ |
| description |
Since the discovery of the 'formose reaction' by Butlerow,[1] total synthesis of carbohydrates has undergone rapid development. The most important methods for the asymmetric synthesis of monosaccharides and analogues of biological importance are presented. Nowadays any natural
and non-natural monosaccharide can be prepared pure in both enantiomeric forms starting from inexpensive starting materials. Metal-based asymmetric catalysis and organocatalysis have been successfully applied, alone or in combination with chemoenzymatic methods. Alternative methods rely upon
substrate- or reagent- controlled diastereo- and enantioselective reactions. Suitably protected carbohydrates have been prepared by total synthesis, thus allowing their direct use in the preparation of oligosaccharides and analogues.[2]
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| first_indexed | 2024-12-24T00:16:25Z |
| format | Article |
| id | doaj.art-fa03de143c9a4d6c802699198311f1c9 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-12-24T00:16:25Z |
| publishDate | 2011-02-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-fa03de143c9a4d6c802699198311f1c92022-12-21T17:24:44ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242011-02-01651-210.2533/chimia.2011.85Total Asymmetric Synthesis of Monosaccharides and AnaloguesInmaculada Robina0Ana T. Carmona1Antonio J. Moreno-Vargas2Elena Moreno-Clavijo3Department of Organic Chemistry Faculty of Chemistry University of Seville, Prof. Garcia González, 1 41012-Seville, Spain;, Email: robina@us.esDepartment of Organic Chemistry Faculty of Chemistry University of Seville, Prof. Garcia González, 1 41012-Seville, SpainDepartment of Organic Chemistry Faculty of Chemistry University of Seville, Prof. Garcia González, 1 41012-Seville, SpainDepartment of Organic Chemistry Faculty of Chemistry University of Seville, Prof. Garcia González, 1 41012-Seville, Spain; Since the discovery of the 'formose reaction' by Butlerow,[1] total synthesis of carbohydrates has undergone rapid development. The most important methods for the asymmetric synthesis of monosaccharides and analogues of biological importance are presented. Nowadays any natural and non-natural monosaccharide can be prepared pure in both enantiomeric forms starting from inexpensive starting materials. Metal-based asymmetric catalysis and organocatalysis have been successfully applied, alone or in combination with chemoenzymatic methods. Alternative methods rely upon substrate- or reagent- controlled diastereo- and enantioselective reactions. Suitably protected carbohydrates have been prepared by total synthesis, thus allowing their direct use in the preparation of oligosaccharides and analogues.[2] https://www.chimia.ch/chimia/article/view/4965AldolaseAllylationAsymmetric aldolChain elongationDihydroxylationEpoxidation |
| spellingShingle | Inmaculada Robina Ana T. Carmona Antonio J. Moreno-Vargas Elena Moreno-Clavijo Total Asymmetric Synthesis of Monosaccharides and Analogues CHIMIA Aldolase Allylation Asymmetric aldol Chain elongation Dihydroxylation Epoxidation |
| title | Total Asymmetric Synthesis of Monosaccharides and Analogues |
| title_full | Total Asymmetric Synthesis of Monosaccharides and Analogues |
| title_fullStr | Total Asymmetric Synthesis of Monosaccharides and Analogues |
| title_full_unstemmed | Total Asymmetric Synthesis of Monosaccharides and Analogues |
| title_short | Total Asymmetric Synthesis of Monosaccharides and Analogues |
| title_sort | total asymmetric synthesis of monosaccharides and analogues |
| topic | Aldolase Allylation Asymmetric aldol Chain elongation Dihydroxylation Epoxidation |
| url | https://www.chimia.ch/chimia/article/view/4965 |
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