Semisynthesis of Taxol®: An improved procedure for the isolation of 10-deacetylbaccatin III
From the needles of domestic yew, (Taxus baccata), 10-deacetylbaccatin III (10-DAB) can be isolated in quantities of up to 297 mg per kg of fresh needles. Additional quantities of 10-Dcan be obtained from the extract by NaBH4 mediated reductive hydrolysis of baccatin esters. A four-step...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Serbian Chemical Society
1999-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/1999/0352-51399909497S.pdf |
| Summary: | From the needles of domestic yew, (Taxus baccata), 10-deacetylbaccatin III
(10-DAB) can be isolated in quantities of up to 297 mg per kg of fresh
needles. Additional quantities of 10-Dcan be obtained from the extract by
NaBH4 mediated reductive hydrolysis of baccatin esters. A four-step
procedure converts 10-Dinto taxol in 58% overall yield. |
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| ISSN: | 0352-5139 1820-7421 |