A Label-Free Optical Biosensor Based on an Array of Microring Resonators for the Detection of Human Serum Albumin

We introduced a label-free sensing system based on an array of microring resonators (MRRs) which was successfully employed for human serum albumin (HSA) detection. The sensing-ring surface was functionalized to immobilize anti-HSA, facilitating HSA binding. Our refractive index sensing system demons...

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Бібліографічні деталі
Автори: Xin Chen, Mingyu Li, Zhaoyu Wang, Kaihao Zhao, Jiamei Gu, Qiushun Li, Jian-Jun He
Формат: Стаття
Мова:English
Опубліковано: MDPI AG 2024-01-01
Серія:Sensors
Предмети:
Онлайн доступ:https://www.mdpi.com/1424-8220/24/2/677
Опис
Резюме:We introduced a label-free sensing system based on an array of microring resonators (MRRs) which was successfully employed for human serum albumin (HSA) detection. The sensing-ring surface was functionalized to immobilize anti-HSA, facilitating HSA binding. Our refractive index sensing system demonstrates high sensitivity at 168 nm/RIU and a low limit of detection (LOD) of 63.54 ng/mL, closely comparable to current HSA detection methods. These findings confirm the potential of MRRs as biocompatible sensors for HSA detection. This system holds great promise as an innovative platform for the detection of HSA, carrying significant importance in medical diagnostics.
ISSN:1424-8220